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- W4310366956 abstract "As an integral part of the innate immune system, the NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome orchestrates the inflammatory response following injury. Activation of the NLRP3 inflammasome and its major product interleukin (IL)-1β are central to the pathogenesis of a wide array of cardiovascular diseases ranging from atherosclerosis to acute myocardial infarction and heart failure, and from inflammatory heart disease to peripheral artery disease and venous thromboembolism. Assembly of the NLRP3 inflammasome has been reported in leukocytes, fibroblasts, cardiomyocytes, platelets, and the endothelium, in which it regulates cellular responses to acute and chronic damage. NLRP3 inhibitors have been developed and investigated in preclinical and early phase clinical studies with encouraging results awaiting validation. In phase II–III clinical trials, inhibition of IL-1β and IL-6, downstream of the inflammasome, has been shown to be safe with a promising efficacy profile across a variety of cardiovascular disorders. While further investigation is ongoing, anakinra and rilonacept, two IL-1 blockers, have recently become standard-of-care for the treatment of recurrent pericarditis. This chapter provides an overview of the available preclinical and clinical findings supporting the central role of the inflammasome and related cytokines including IL-1β and IL-18 in the more common cardiovascular diseases." @default.
- W4310366956 created "2022-12-09" @default.
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- W4310366956 date "2023-01-01" @default.
- W4310366956 modified "2023-09-25" @default.
- W4310366956 title "The inflammasome in cardiovascular diseases" @default.
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- W4310366956 doi "https://doi.org/10.1016/b978-0-323-91802-2.00024-4" @default.
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