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- W4310367062 endingPage "32" @default.
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- W4310367062 abstract "Inflammasomes are intracellular sensors of pathogens and guardians of cell well-being. Microbial, endogenous, and synthetic triggers either directly or indirectly induce the assembly of an inflammasome that consists of a receptor/sensor, an adaptor, and a proinflammatory caspase such as caspase-1. Activated caspase-1 exerts its effector functions by cleaving proinflammatory cytokines pro-IL-1β and pro-IL-18. Inflammatory caspases also cleave gasdermin D which enables its N-terminal domain to form pores in the plasma membrane. Excessive pore formation leads to ninjurin-1-mediated plasma membrane rupture and cell death called pyroptosis. Inflammasome sensors undergo quite distinct modes of activation. Some sensors such as AIM2 recognize their activators directly, others such as Pyrin sense pathogen activity instead. In this chapter, the basic principles of inflammasomes will be presented and mechanisms of activation of several inflammasomes will be explained to introduce the reader to the fascinating world of these intracellular inflammatory devices." @default.
- W4310367062 created "2022-12-09" @default.
- W4310367062 creator A5054301904 @default.
- W4310367062 date "2023-01-01" @default.
- W4310367062 modified "2023-09-27" @default.
- W4310367062 title "Inflammasome formation and triggers" @default.
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