Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310367067> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4310367067 endingPage "426" @default.
- W4310367067 startingPage "421" @default.
- W4310367067 abstract "Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic cell transplantation (allo-HCT) performed in leukemia patients, where donor immune cells attack recipient tissues. The activation of the NLR pyrin family domain 3 (NLRP3) inflammasome plays a key role in the pathogenesis of acute GVHD as sown in multiple mouse models. The NLRP3 activation in myeloid cells after allo-HCT leads to the release of bioactive IL-1β and IL-18 which amplify immune responses and enhance GVHD. Also NLRP3 activation blocks the tolerogenic activity of myeloid-derived suppressor cells which normally protect from acute GVHD in mice. In patients the recipient NLRP3 CC genotype was connected to the incidence of severe acute GVHD. This chapter reviews how NLRP3 activation leads to immunopathology during GVHD with a specific focus on innate immune cells, the role of the danger signals and the resulting clinical manifestations." @default.
- W4310367067 created "2022-12-09" @default.
- W4310367067 creator A5000708356 @default.
- W4310367067 creator A5084803299 @default.
- W4310367067 date "2023-01-01" @default.
- W4310367067 modified "2023-09-27" @default.
- W4310367067 title "The inflammasome in graft-versus-host disease" @default.
- W4310367067 cites W1592407962 @default.
- W4310367067 cites W1830619435 @default.
- W4310367067 cites W1834407877 @default.
- W4310367067 cites W1870543278 @default.
- W4310367067 cites W1995355078 @default.
- W4310367067 cites W2038908080 @default.
- W4310367067 cites W2129388928 @default.
- W4310367067 cites W2131766513 @default.
- W4310367067 cites W2146496194 @default.
- W4310367067 cites W2173905909 @default.
- W4310367067 cites W2298225937 @default.
- W4310367067 cites W2310441748 @default.
- W4310367067 cites W2479125356 @default.
- W4310367067 cites W2621741324 @default.
- W4310367067 cites W2739584330 @default.
- W4310367067 cites W2763815202 @default.
- W4310367067 cites W2769990542 @default.
- W4310367067 cites W2789970879 @default.
- W4310367067 cites W2795193038 @default.
- W4310367067 cites W2917200176 @default.
- W4310367067 cites W2973964142 @default.
- W4310367067 cites W2974871811 @default.
- W4310367067 cites W2990824191 @default.
- W4310367067 cites W2995530076 @default.
- W4310367067 cites W3014242925 @default.
- W4310367067 cites W3017383148 @default.
- W4310367067 cites W3034460136 @default.
- W4310367067 cites W3036446761 @default.
- W4310367067 cites W3095726304 @default.
- W4310367067 cites W3118531686 @default.
- W4310367067 cites W3183219171 @default.
- W4310367067 cites W4247737273 @default.
- W4310367067 doi "https://doi.org/10.1016/b978-0-323-91802-2.00005-0" @default.
- W4310367067 hasPublicationYear "2023" @default.
- W4310367067 type Work @default.
- W4310367067 citedByCount "0" @default.
- W4310367067 crossrefType "book-chapter" @default.
- W4310367067 hasAuthorship W4310367067A5000708356 @default.
- W4310367067 hasAuthorship W4310367067A5084803299 @default.
- W4310367067 hasConcept C136449434 @default.
- W4310367067 hasConcept C139174496 @default.
- W4310367067 hasConcept C142724271 @default.
- W4310367067 hasConcept C203014093 @default.
- W4310367067 hasConcept C2776914184 @default.
- W4310367067 hasConcept C2777209026 @default.
- W4310367067 hasConcept C2777408962 @default.
- W4310367067 hasConcept C2778729363 @default.
- W4310367067 hasConcept C2779134260 @default.
- W4310367067 hasConcept C2779282312 @default.
- W4310367067 hasConcept C2779972918 @default.
- W4310367067 hasConcept C2780942790 @default.
- W4310367067 hasConcept C71924100 @default.
- W4310367067 hasConcept C8891405 @default.
- W4310367067 hasConceptScore W4310367067C136449434 @default.
- W4310367067 hasConceptScore W4310367067C139174496 @default.
- W4310367067 hasConceptScore W4310367067C142724271 @default.
- W4310367067 hasConceptScore W4310367067C203014093 @default.
- W4310367067 hasConceptScore W4310367067C2776914184 @default.
- W4310367067 hasConceptScore W4310367067C2777209026 @default.
- W4310367067 hasConceptScore W4310367067C2777408962 @default.
- W4310367067 hasConceptScore W4310367067C2778729363 @default.
- W4310367067 hasConceptScore W4310367067C2779134260 @default.
- W4310367067 hasConceptScore W4310367067C2779282312 @default.
- W4310367067 hasConceptScore W4310367067C2779972918 @default.
- W4310367067 hasConceptScore W4310367067C2780942790 @default.
- W4310367067 hasConceptScore W4310367067C71924100 @default.
- W4310367067 hasConceptScore W4310367067C8891405 @default.
- W4310367067 hasLocation W43103670671 @default.
- W4310367067 hasOpenAccess W4310367067 @default.
- W4310367067 hasPrimaryLocation W43103670671 @default.
- W4310367067 hasRelatedWork W2130940574 @default.
- W4310367067 hasRelatedWork W2138838898 @default.
- W4310367067 hasRelatedWork W2160038863 @default.
- W4310367067 hasRelatedWork W2561821224 @default.
- W4310367067 hasRelatedWork W2799294463 @default.
- W4310367067 hasRelatedWork W2945769997 @default.
- W4310367067 hasRelatedWork W3022001611 @default.
- W4310367067 hasRelatedWork W4240510062 @default.
- W4310367067 hasRelatedWork W4254536103 @default.
- W4310367067 hasRelatedWork W4307944306 @default.
- W4310367067 isParatext "false" @default.
- W4310367067 isRetracted "false" @default.
- W4310367067 workType "book-chapter" @default.