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- W4310367445 abstract "Hoodia gordonii (Masson) Sweet ex Decne. (Apocynaceae), commonly known as bitterghaap, is a spiny succulent plant with rows of small thorns visible along the fairly hard and fleshy, glabrous, grey-brown to grey-green stems. The plant has a narrow geographical distribution, but is widely distributed throughout the dry, desert areas of South Africa and Namibia. Traditionally, the Khoisan people in southern Africa sucked on Hoodia stems while on long hunting trips to quench hunger and thirst. It is also said that the stems were used traditionally in the treatment of tuberculosis, and honey from the flowers was used to treat cancer. The commercialisation of this plant as an anti-obesity agent has been highly controversial due to benefit-sharing issues and intellectual property rights. Although no commercial product has been developed due to efficacy and safety concerns, some Hoodia herbal products are available on the market. The Council for Scientific and Industrial Research (CSIR) isolated and patented the pregnane glycoside P57 in 1995. Since then the phytochemistry has been extensively researched. In vitro and in vivo biological activities investigated include appetite-suppressant, antidiabetic, anti-inflammatory and antidepressant activities, as well as the pharmacokinetics and biopharmaceutics of various compounds. Using semi-automated high-performance thin-layer chromatography (HPTLC), ultra-performance liquid chromatography coupled with mass spectrometry (UPLC–MS), and mid-infrared (MIR) spectroscopy, the chemical profiles of H. gordonii methanol extracts were obtained. The marker compound P57 of H. gordonii was identified in the chemical fingerprints of all the samples on HPTLC plates viewed under 366 nm radiation, and UPLC–MS chromatograms confirmed the presence of the compound." @default.
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- W4310367445 date "2023-01-01" @default.
- W4310367445 modified "2023-09-27" @default.
- W4310367445 title "Hoodia gordonii" @default.
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- W4310367445 doi "https://doi.org/10.1016/b978-0-323-99794-2.00018-0" @default.
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