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• W4310371152 endingPage "14958" @default.
• W4310371152 startingPage "14958" @default.
• W4310371152 abstract "Autoimmune hypophysitis (AH) is an autoimmune disease of the pituitary for which the pathogenesis is incompletely known. AH is often treated with corticosteroids; however, steroids may lead to considerable side effects. Using a mouse model of AH (experimental autoimmune hypophysitis, EAH), we show that interleukin-1 receptor-associated kinase 1 (IRAK1) is upregulated in the pituitaries of mice that developed EAH. We identified rosoxacin as a specific inhibitor for IRAK1 and found it could treat EAH. Rosoxacin treatment at an early stage (day 0–13) slightly reduced disease severity, whereas treatment at a later stage (day 14–27) significantly suppressed EAH. Further investigation indicated rosoxacin reduced production of autoantigen-specific antibodies. Rosoxacin downregulated production of cytokines and chemokines that may dampen T cell differentiation or recruitment to the pituitary. Finally, rosoxacin downregulated class II major histocompatibility complex expression on antigen-presenting cells that may lead to impaired activation of autoantigen-specific T cells. These data suggest that IRAK1 may play a pathogenic role in AH and that rosoxacin may be an effective drug for AH and other inflammatory diseases involving IRAK1 dysregulation." @default.
• W4310371152 created "2022-12-09" @default.
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• W4310371152 date "2022-11-29" @default.
• W4310371152 modified "2023-09-26" @default.
• W4310371152 title "Inhibition of IRAK1 Is an Effective Therapy for Autoimmune Hypophysitis in Mice" @default.
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• W4310371152 doi "https://doi.org/10.3390/ijms232314958" @default.
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