FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310371208> ?p ?o ?g. }

• W4310371208 abstract "Hepatocellular carcinoma (HCC) is a common malignant tumor with a poor prognosis. Epigenetic dysregulation is now considered to be related to hepatocarcinogenesis. However, it is unclear how epigenetic-related genes (ERGs) contribute to the prognosis of HCC. In this study, we used the TCGA database to identify prognostic ERGs that were differentially expressed in HCC patients. Then, using least absolute shrinkage and selection operator (LASSO) regression analysis, a six-gene signature was constructed, and patients were divided into high- and low-risk groups. Validation was performed on HCC patients from the ICGC database. Patients in the high-risk group had a significantly lower chance of survival than those in the low-risk group (p < 0.001 in both databases). The predictive ability of the signature was determined by the receiver operating characteristic (ROC) curve. The risk score was then shown to be an independent prognostic factor for the overall survival (OS) of HCC patients based on the results of univariate and multivariate analyses. We also created a practical nomogram combining the prognostic model with other clinical features. Moreover, functional enrichment analysis revealed that these genes are linked to tumor immunity. In conclusion, our findings showed that a novel six-gene signature related to epigenetics can accurately predict the occurrence and prognosis of HCC." @default.
• W4310371208 created "2022-12-09" @default.
• W4310371208 creator A5002118503 @default.
• W4310371208 creator A5004726461 @default.
• W4310371208 creator A5012278873 @default.
• W4310371208 creator A5050823509 @default.
• W4310371208 creator A5055438121 @default.
• W4310371208 creator A5065856990 @default.
• W4310371208 creator A5066279044 @default.
• W4310371208 creator A5072700717 @default.
• W4310371208 creator A5073971431 @default.
• W4310371208 creator A5081341048 @default.
• W4310371208 date "2022-11-30" @default.
• W4310371208 modified "2023-09-24" @default.
• W4310371208 title "Identification and verification of a novel epigenetic-related gene signature for predicting the prognosis of hepatocellular carcinoma" @default.
• W4310371208 cites W1964965071 @default.
• W4310371208 cites W1968228591 @default.
• W4310371208 cites W1986220715 @default.
• W4310371208 cites W1995908731 @default.
• W4310371208 cites W1999478182 @default.
• W4310371208 cites W2037139350 @default.
• W4310371208 cites W2041402229 @default.
• W4310371208 cites W2087513381 @default.
• W4310371208 cites W2110878284 @default.
• W4310371208 cites W2124302786 @default.
• W4310371208 cites W2139232339 @default.
• W4310371208 cites W2149199519 @default.
• W4310371208 cites W2519632406 @default.
• W4310371208 cites W2550502448 @default.
• W4310371208 cites W2564460377 @default.
• W4310371208 cites W2614910530 @default.
• W4310371208 cites W2770519623 @default.
• W4310371208 cites W2782248232 @default.
• W4310371208 cites W2791216463 @default.
• W4310371208 cites W2805162488 @default.
• W4310371208 cites W2889769350 @default.
• W4310371208 cites W2890897078 @default.
• W4310371208 cites W2907808933 @default.
• W4310371208 cites W2949179534 @default.
• W4310371208 cites W2953728710 @default.
• W4310371208 cites W2969944855 @default.
• W4310371208 cites W2987662413 @default.
• W4310371208 cites W2993425070 @default.
• W4310371208 cites W2996975235 @default.
• W4310371208 cites W3005937021 @default.
• W4310371208 cites W3006367000 @default.
• W4310371208 cites W3020424172 @default.
• W4310371208 cites W3029777522 @default.
• W4310371208 cites W3033218405 @default.
• W4310371208 cites W3040342671 @default.
• W4310371208 cites W3046633815 @default.
• W4310371208 cites W3081017028 @default.
• W4310371208 cites W3092778940 @default.
• W4310371208 cites W3093534666 @default.
• W4310371208 cites W3100629716 @default.
• W4310371208 cites W3110314789 @default.
• W4310371208 cites W3118017075 @default.
• W4310371208 cites W3159135758 @default.
• W4310371208 cites W4221045277 @default.
• W4310371208 cites W4232620598 @default.
• W4310371208 cites W4288069643 @default.
• W4310371208 cites W4304208568 @default.
• W4310371208 doi "https://doi.org/10.3389/fgene.2022.897123" @default.
• W4310371208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36531219" @default.
• W4310371208 hasPublicationYear "2022" @default.
• W4310371208 type Work @default.
• W4310371208 citedByCount "0" @default.
• W4310371208 crossrefType "journal-article" @default.
• W4310371208 hasAuthorship W4310371208A5002118503 @default.
• W4310371208 hasAuthorship W4310371208A5004726461 @default.
• W4310371208 hasAuthorship W4310371208A5012278873 @default.
• W4310371208 hasAuthorship W4310371208A5050823509 @default.
• W4310371208 hasAuthorship W4310371208A5055438121 @default.
• W4310371208 hasAuthorship W4310371208A5065856990 @default.
• W4310371208 hasAuthorship W4310371208A5066279044 @default.
• W4310371208 hasAuthorship W4310371208A5072700717 @default.
• W4310371208 hasAuthorship W4310371208A5073971431 @default.
• W4310371208 hasAuthorship W4310371208A5081341048 @default.
• W4310371208 hasBestOaLocation W43103712081 @default.
• W4310371208 hasConcept C104317684 @default.
• W4310371208 hasConcept C119857082 @default.
• W4310371208 hasConcept C126322002 @default.
• W4310371208 hasConcept C143998085 @default.
• W4310371208 hasConcept C144301174 @default.
• W4310371208 hasConcept C150194340 @default.
• W4310371208 hasConcept C161584116 @default.
• W4310371208 hasConcept C199163554 @default.
• W4310371208 hasConcept C2778019345 @default.
• W4310371208 hasConcept C2779733811 @default.
• W4310371208 hasConcept C34626388 @default.
• W4310371208 hasConcept C38180746 @default.
• W4310371208 hasConcept C41008148 @default.
• W4310371208 hasConcept C41091548 @default.
• W4310371208 hasConcept C54355233 @default.
• W4310371208 hasConcept C58471807 @default.
• W4310371208 hasConcept C71924100 @default.
• W4310371208 hasConcept C86803240 @default.
• W4310371208 hasConceptScore W4310371208C104317684 @default.
• W4310371208 hasConceptScore W4310371208C119857082 @default.
• W4310371208 hasConceptScore W4310371208C126322002 @default.

• next