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- W4310371209 endingPage "14968" @default.
- W4310371209 startingPage "14968" @default.
- W4310371209 abstract "Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota-gut-brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut-brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut-brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches." @default.
- W4310371209 created "2022-12-09" @default.
- W4310371209 creator A5010095184 @default.
- W4310371209 creator A5012503420 @default.
- W4310371209 creator A5041742679 @default.
- W4310371209 date "2022-11-29" @default.
- W4310371209 modified "2023-09-26" @default.
- W4310371209 title "Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis" @default.
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