FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310376001> ?p ?o ?g. }

• W4310376001 abstract "Acute graft versus host disease (aGVHD) is a rare, but severe complication of liver transplantation (LT). It is caused by the activation of donor immune cells in the graft against the host shortly after transplantation, but the contributing pathogenic factors remain unclear. Here we show that human T cell lymphotropic virus type I (HTLV-1) infection of donor T cells is highly associated with aGVHD following LT. The presence of HTLV-1 in peripheral blood and tissue samples from a discovery cohort of 7 aGVHD patients and 17 control patients is assessed with hybridization probes (TargetSeq), mass cytometry (CyTOF), and multiplex immunohistology (IMC). All 7 of our aGVHD patients display detectable HTLV-1 Tax signals by IMC. We identify donor-derived cells based on a Y chromosome-specific genetic marker, EIF1AY. Thus, we confirm the presence of CD4+Tax+EIF1AY+ T cells and Tax+CD68+EIF1AY+ antigen-presenting cells, indicating HTLV-1 infection of donor immune cells. In an independent cohort of 400 patients, we verify that HTLV-1 prevalence correlates with aGVHD incidence, while none of the control viruses shows significant associations. Our findings thus provide new insights into the aetio-pathology of liver-transplantation-associated aGVHD and raise the possibility of preventing aGVHD prior to transplantation." @default.
• W4310376001 created "2022-12-10" @default.
• W4310376001 creator A5010115091 @default.
• W4310376001 creator A5014838569 @default.
• W4310376001 creator A5027269279 @default.
• W4310376001 creator A5035281933 @default.
• W4310376001 creator A5050051337 @default.
• W4310376001 creator A5064181978 @default.
• W4310376001 creator A5072257981 @default.
• W4310376001 creator A5078080137 @default.
• W4310376001 creator A5080924951 @default.
• W4310376001 creator A5087108704 @default.
• W4310376001 creator A5087581056 @default.
• W4310376001 date "2022-11-30" @default.
• W4310376001 modified "2023-10-16" @default.
• W4310376001 title "HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation" @default.
• W4310376001 cites W1530764705 @default.
• W4310376001 cites W1968812065 @default.
• W4310376001 cites W1975370283 @default.
• W4310376001 cites W198915280 @default.
• W4310376001 cites W1993229072 @default.
• W4310376001 cites W1995675450 @default.
• W4310376001 cites W2002353148 @default.
• W4310376001 cites W2004586897 @default.
• W4310376001 cites W2006036488 @default.
• W4310376001 cites W2016290959 @default.
• W4310376001 cites W2017848406 @default.
• W4310376001 cites W2019559865 @default.
• W4310376001 cites W2029525607 @default.
• W4310376001 cites W2033259350 @default.
• W4310376001 cites W2034952320 @default.
• W4310376001 cites W2037297987 @default.
• W4310376001 cites W2041758085 @default.
• W4310376001 cites W2042431910 @default.
• W4310376001 cites W2054124482 @default.
• W4310376001 cites W2055014838 @default.
• W4310376001 cites W2065006357 @default.
• W4310376001 cites W2068414487 @default.
• W4310376001 cites W2088611201 @default.
• W4310376001 cites W2096921306 @default.
• W4310376001 cites W2098777645 @default.
• W4310376001 cites W2123895023 @default.
• W4310376001 cites W2125841464 @default.
• W4310376001 cites W2127679709 @default.
• W4310376001 cites W2142328433 @default.
• W4310376001 cites W2147372038 @default.
• W4310376001 cites W2211762459 @default.
• W4310376001 cites W2299990744 @default.
• W4310376001 cites W2329092215 @default.
• W4310376001 cites W2467358155 @default.
• W4310376001 cites W2522948376 @default.
• W4310376001 cites W2525801414 @default.
• W4310376001 cites W2562983292 @default.
• W4310376001 cites W2606281735 @default.
• W4310376001 cites W2746753481 @default.
• W4310376001 cites W2769209815 @default.
• W4310376001 cites W2769990542 @default.
• W4310376001 cites W2770683875 @default.
• W4310376001 cites W2775846177 @default.
• W4310376001 cites W2791053963 @default.
• W4310376001 cites W2804956034 @default.
• W4310376001 cites W2893383899 @default.
• W4310376001 cites W2899838010 @default.
• W4310376001 cites W2946094964 @default.
• W4310376001 cites W2958364068 @default.
• W4310376001 cites W2978713746 @default.
• W4310376001 cites W2990270474 @default.
• W4310376001 cites W3100153227 @default.
• W4310376001 cites W3108355811 @default.
• W4310376001 cites W3156504459 @default.
• W4310376001 cites W4250130341 @default.
• W4310376001 cites W4376542676 @default.
• W4310376001 doi "https://doi.org/10.1038/s41467-022-35111-w" @default.
• W4310376001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36450748" @default.
• W4310376001 hasPublicationYear "2022" @default.
• W4310376001 type Work @default.
• W4310376001 citedByCount "1" @default.
• W4310376001 countsByYear W43103760012023 @default.
• W4310376001 crossrefType "journal-article" @default.
• W4310376001 hasAuthorship W4310376001A5010115091 @default.
• W4310376001 hasAuthorship W4310376001A5014838569 @default.
• W4310376001 hasAuthorship W4310376001A5027269279 @default.
• W4310376001 hasAuthorship W4310376001A5035281933 @default.
• W4310376001 hasAuthorship W4310376001A5050051337 @default.
• W4310376001 hasAuthorship W4310376001A5064181978 @default.
• W4310376001 hasAuthorship W4310376001A5072257981 @default.
• W4310376001 hasAuthorship W4310376001A5078080137 @default.
• W4310376001 hasAuthorship W4310376001A5080924951 @default.
• W4310376001 hasAuthorship W4310376001A5087108704 @default.
• W4310376001 hasAuthorship W4310376001A5087581056 @default.
• W4310376001 hasBestOaLocation W43103760011 @default.
• W4310376001 hasConcept C126322002 @default.
• W4310376001 hasConcept C203014093 @default.
• W4310376001 hasConcept C2779609443 @default.
• W4310376001 hasConcept C2779972918 @default.
• W4310376001 hasConcept C2911091166 @default.
• W4310376001 hasConcept C71924100 @default.
• W4310376001 hasConcept C86803240 @default.
• W4310376001 hasConcept C8891405 @default.
• W4310376001 hasConceptScore W4310376001C126322002 @default.

• next