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• W4310376944 endingPage "2049" @default.
• W4310376944 startingPage "2049" @default.
• W4310376944 abstract "In view of the severe downsides of conventional cancer therapies, the quest of developing alternative strategies still remains of critical importance. In this regard, antigen cross-presentation, usually employed by dendritic cells (DCs), has been recognized as a potential solution to overcome the present impasse in anti-cancer therapeutic strategies. It has been established that an elevated cytotoxic T lymphocyte (CTL) response against cancer cells can be achieved by targeting receptors expressed on DCs with specific ligands. Glycans are known to serve as ligands for C-type lectin receptors (CLRs) expressed on DCs, and are also known to act as a tumor-associated antigen (TAA), and, thus, can be harnessed as a potential immunotherapeutic target. In this scenario, integrating the knowledge of cross-presentation and glycan-conjugated nanovaccines can help us to develop so called 'glyco-nanovaccines' (GNVs) for targeting DCs. Here, we briefly review and analyze the potential of GNVs as the next-generation anti-tumor immunotherapy. We have compared different antigen-presenting cells (APCs) for their ability to cross-present antigens and described the potential nanocarriers for tumor antigen cross-presentation. Further, we discuss the role of glycans in targeting of DCs, the immune response due to pathogens, and imitative approaches, along with parameters, strategies, and challenges involved in cross-presentation-based GNVs for cancer immunotherapy. It is known that the effectiveness of GNVs in eradicating tumors by inducing strong CTL response in the tumor microenvironment (TME) has been largely hindered by tumor glycosylation and the expression of different lectin receptors (such as galectins) by cancer cells. Tumor glycan signatures can be sensed by a variety of lectins expressed on immune cells and mediate the immune suppression which, in turn, facilitates immune evasion. Therefore, a sound understanding of the glycan language of cancer cells, and glycan-lectin interaction between the cancer cells and immune cells, would help in strategically designing the next-generation GNVs for anti-tumor immunotherapy." @default.
• W4310376944 created "2022-12-10" @default.
• W4310376944 creator A5015696485 @default.
• W4310376944 creator A5034304968 @default.
• W4310376944 creator A5056377592 @default.
• W4310376944 creator A5068310098 @default.
• W4310376944 creator A5072002824 @default.
• W4310376944 date "2022-11-30" @default.
• W4310376944 modified "2023-09-26" @default.
• W4310376944 title "Canvassing Prospects of Glyco-Nanovaccines for Developing Cross-Presentation Mediated Anti-Tumor Immunotherapy" @default.
• W4310376944 cites W1182461782 @default.
• W4310376944 cites W1507548252 @default.
• W4310376944 cites W1517310071 @default.
• W4310376944 cites W1517698264 @default.
• W4310376944 cites W1522079064 @default.
• W4310376944 cites W1534496719 @default.
• W4310376944 cites W1587935721 @default.
• W4310376944 cites W1601925808 @default.
• W4310376944 cites W1655860314 @default.
• W4310376944 cites W1661544713 @default.
• W4310376944 cites W1669974101 @default.
• W4310376944 cites W1693991445 @default.
• W4310376944 cites W1792232742 @default.
• W4310376944 cites W17966201 @default.
• W4310376944 cites W1841032638 @default.
• W4310376944 cites W1856206988 @default.
• W4310376944 cites W1894685526 @default.
• W4310376944 cites W1905688966 @default.
• W4310376944 cites W1906986428 @default.
• W4310376944 cites W1964144818 @default.
• W4310376944 cites W1965146817 @default.
• W4310376944 cites W1966656613 @default.
• W4310376944 cites W1967660147 @default.
• W4310376944 cites W1968091639 @default.
• W4310376944 cites W1968830740 @default.
• W4310376944 cites W1969602339 @default.
• W4310376944 cites W1972141585 @default.
• W4310376944 cites W1975091484 @default.
• W4310376944 cites W1976792034 @default.
• W4310376944 cites W1976925504 @default.
• W4310376944 cites W1980359886 @default.
• W4310376944 cites W1981760171 @default.
• W4310376944 cites W1985144544 @default.
• W4310376944 cites W1987053745 @default.
• W4310376944 cites W1988097468 @default.
• W4310376944 cites W1988569486 @default.
• W4310376944 cites W1988869609 @default.
• W4310376944 cites W1988940275 @default.
• W4310376944 cites W1989037178 @default.
• W4310376944 cites W1990189976 @default.
• W4310376944 cites W1990459651 @default.
• W4310376944 cites W1991240417 @default.
• W4310376944 cites W1993511309 @default.
• W4310376944 cites W1995744610 @default.
• W4310376944 cites W1995805772 @default.
• W4310376944 cites W1997276741 @default.
• W4310376944 cites W1997408488 @default.
• W4310376944 cites W1997496320 @default.
• W4310376944 cites W1998256354 @default.
• W4310376944 cites W1998509382 @default.
• W4310376944 cites W2001268204 @default.
• W4310376944 cites W2002176017 @default.
• W4310376944 cites W2003612288 @default.
• W4310376944 cites W2004773897 @default.
• W4310376944 cites W2007058937 @default.
• W4310376944 cites W2008657060 @default.
• W4310376944 cites W2012267998 @default.
• W4310376944 cites W2012741202 @default.
• W4310376944 cites W2013111518 @default.
• W4310376944 cites W2017445493 @default.
• W4310376944 cites W2017705352 @default.
• W4310376944 cites W2019671439 @default.
• W4310376944 cites W2024787650 @default.
• W4310376944 cites W2028084107 @default.
• W4310376944 cites W2028292642 @default.
• W4310376944 cites W2029565478 @default.
• W4310376944 cites W2030744360 @default.
• W4310376944 cites W2031039028 @default.
• W4310376944 cites W2031172552 @default.
• W4310376944 cites W2031566097 @default.
• W4310376944 cites W2032760352 @default.
• W4310376944 cites W2032991215 @default.
• W4310376944 cites W2033193662 @default.
• W4310376944 cites W2034570325 @default.
• W4310376944 cites W2039085998 @default.
• W4310376944 cites W2039759758 @default.
• W4310376944 cites W2039947109 @default.
• W4310376944 cites W2041659209 @default.
• W4310376944 cites W2043769866 @default.
• W4310376944 cites W2044471952 @default.
• W4310376944 cites W2046148841 @default.
• W4310376944 cites W2048000602 @default.
• W4310376944 cites W2050087312 @default.
• W4310376944 cites W2051184702 @default.
• W4310376944 cites W2053346961 @default.
• W4310376944 cites W2053400250 @default.
• W4310376944 cites W2054336884 @default.
• W4310376944 cites W2056628849 @default.

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