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• W4310398099 abstract "CUO246, a novel DNA gyrase/topoisomerase IV inhibitor, is active in vitro against a broad range of Gram-positive, fastidious Gram-negative, and atypical bacterial pathogens and retains activity against quinolone-resistant strains in circulation. The frequency of selection for single step mutants of wild-type S. aureus with reduced susceptibility to CUO246 was <4.64 × 10 −9 at 4× and 8× MIC and remained low when using an isogenic QRDR mutant (<5.24 × 10 −9 at 4× and 8× MIC)." @default.
• W4310398099 created "2022-12-10" @default.
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• W4310398099 date "2022-12-20" @default.
• W4310398099 modified "2023-10-07" @default.
• W4310398099 title "<i>In Vitro</i> and <i>In Vivo</i> Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor" @default.
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• W4310398099 doi "https://doi.org/10.1128/aac.00921-22" @default.
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