Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310422014> ?p ?o ?g. }
- W4310422014 endingPage "105693" @default.
- W4310422014 startingPage "105693" @default.
- W4310422014 abstract "Avian influenza H5N6 virus not only wreaks economic havoc in the poultry industry but also threatens human health. Strikingly, as of August 2022, 78 human beings were infected with H5N6, and the spike in the number of human infections with H5N6 occurred during 2021. In the life cycle of influenza virus, neuraminidase (NA) has numerous functions, especially viral budding and replication. Here, we found that NA-D272N mutation became predominant in H5N6 viruses since 2015 and significantly increased the viral replication and virulence in mice. D272N mutation in NA protein increased viral release from erythrocytes, thermostability, early transcription, and accumulation of NA protein. Particularly, the dominant 272 residue switch from N to S has occurred in wild bird-origin H5N6 viruses since late 2016 and N272S mutation induced significantly higher levels of inflammatory cytokines in infected human cells. Therefore, comprehensive surveillance of bird populations needs to be enhanced to monitor mammalian adaptive mutations of H5N6 viruses." @default.
- W4310422014 created "2022-12-10" @default.
- W4310422014 creator A5008659449 @default.
- W4310422014 creator A5014986772 @default.
- W4310422014 creator A5035701638 @default.
- W4310422014 creator A5035796509 @default.
- W4310422014 creator A5036769734 @default.
- W4310422014 creator A5037745816 @default.
- W4310422014 creator A5041449922 @default.
- W4310422014 creator A5059352135 @default.
- W4310422014 creator A5060043527 @default.
- W4310422014 creator A5068064897 @default.
- W4310422014 creator A5079691564 @default.
- W4310422014 date "2022-12-01" @default.
- W4310422014 modified "2023-10-17" @default.
- W4310422014 title "Key amino acid position 272 in neuraminidase determines the replication and virulence of H5N6 avian influenza virus in mammals" @default.
- W4310422014 cites W1493636931 @default.
- W4310422014 cites W1840869898 @default.
- W4310422014 cites W1868415946 @default.
- W4310422014 cites W1939857580 @default.
- W4310422014 cites W1964702822 @default.
- W4310422014 cites W1967283148 @default.
- W4310422014 cites W1973122974 @default.
- W4310422014 cites W1980290172 @default.
- W4310422014 cites W1996311210 @default.
- W4310422014 cites W2003609356 @default.
- W4310422014 cites W2011902730 @default.
- W4310422014 cites W2018594231 @default.
- W4310422014 cites W2020316997 @default.
- W4310422014 cites W2024970913 @default.
- W4310422014 cites W2030895743 @default.
- W4310422014 cites W2052334391 @default.
- W4310422014 cites W2071905917 @default.
- W4310422014 cites W2091527885 @default.
- W4310422014 cites W2092097938 @default.
- W4310422014 cites W2097708737 @default.
- W4310422014 cites W2100985160 @default.
- W4310422014 cites W2102838269 @default.
- W4310422014 cites W2111323042 @default.
- W4310422014 cites W2127774996 @default.
- W4310422014 cites W2136621234 @default.
- W4310422014 cites W2140740881 @default.
- W4310422014 cites W2148994226 @default.
- W4310422014 cites W2150054867 @default.
- W4310422014 cites W2160881014 @default.
- W4310422014 cites W2165690966 @default.
- W4310422014 cites W2193331226 @default.
- W4310422014 cites W2336874512 @default.
- W4310422014 cites W2487040845 @default.
- W4310422014 cites W2514206578 @default.
- W4310422014 cites W2557499142 @default.
- W4310422014 cites W2564814218 @default.
- W4310422014 cites W2624910216 @default.
- W4310422014 cites W2737480209 @default.
- W4310422014 cites W2752080425 @default.
- W4310422014 cites W2772414361 @default.
- W4310422014 cites W2773722402 @default.
- W4310422014 cites W2801022703 @default.
- W4310422014 cites W2802232661 @default.
- W4310422014 cites W2914037739 @default.
- W4310422014 cites W2927178773 @default.
- W4310422014 cites W2938410397 @default.
- W4310422014 cites W2997109716 @default.
- W4310422014 cites W2999985778 @default.
- W4310422014 cites W3009300537 @default.
- W4310422014 cites W3011557637 @default.
- W4310422014 cites W3084852403 @default.
- W4310422014 cites W3093583397 @default.
- W4310422014 cites W3104614331 @default.
- W4310422014 cites W3156805575 @default.
- W4310422014 cites W3160128105 @default.
- W4310422014 cites W3162926003 @default.
- W4310422014 cites W3168314838 @default.
- W4310422014 cites W3216571519 @default.
- W4310422014 cites W4207034476 @default.
- W4310422014 cites W4214491240 @default.
- W4310422014 cites W4224861332 @default.
- W4310422014 cites W4225082646 @default.
- W4310422014 cites W4281790889 @default.
- W4310422014 cites W4283271752 @default.
- W4310422014 cites W4295259933 @default.
- W4310422014 cites W4295776561 @default.
- W4310422014 doi "https://doi.org/10.1016/j.isci.2022.105693" @default.
- W4310422014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36567717" @default.
- W4310422014 hasPublicationYear "2022" @default.
- W4310422014 type Work @default.
- W4310422014 citedByCount "0" @default.
- W4310422014 crossrefType "journal-article" @default.
- W4310422014 hasAuthorship W4310422014A5008659449 @default.
- W4310422014 hasAuthorship W4310422014A5014986772 @default.
- W4310422014 hasAuthorship W4310422014A5035701638 @default.
- W4310422014 hasAuthorship W4310422014A5035796509 @default.
- W4310422014 hasAuthorship W4310422014A5036769734 @default.
- W4310422014 hasAuthorship W4310422014A5037745816 @default.
- W4310422014 hasAuthorship W4310422014A5041449922 @default.
- W4310422014 hasAuthorship W4310422014A5059352135 @default.
- W4310422014 hasAuthorship W4310422014A5060043527 @default.
- W4310422014 hasAuthorship W4310422014A5068064897 @default.