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- W4310423053 endingPage "105685" @default.
- W4310423053 startingPage "105685" @default.
- W4310423053 abstract "Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans. We used electron microscopy with unbiased stereological sampling to assess synaptic ultrastructure in dorsolateral prefrontal cortex (dlPFC) and hippocampal CA1 of female and male rhesus monkeys, four years after three 4-h exposures to sevoflurane during the first five postnatal weeks. This allowed us to ascertain long-term consequences of anesthesia exposure without confounding effects of surgery or illness. Synapse areas were reduced in the largest synapses in CA1 and dlPFC, predominantly in perforated spinous synapses in CA1 and nonperforated spinous synapses in dlPFC. Mitochondrial morphology and localization changed subtly in both areas. Synapse areas in CA1 correlated with response to a mild social stressor. Thus, exposure to anesthesia in infancy can cause long-term ultrastructural changes in primates, which may be substrates for long-term alterations in synaptic transmission and behavioral deficits." @default.
- W4310423053 created "2022-12-10" @default.
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- W4310423053 creator A5067977612 @default.
- W4310423053 date "2022-12-01" @default.
- W4310423053 modified "2023-10-17" @default.
- W4310423053 title "Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life" @default.
- W4310423053 cites W1508083446 @default.
- W4310423053 cites W1649075337 @default.
- W4310423053 cites W1875029981 @default.
- W4310423053 cites W1981875905 @default.
- W4310423053 cites W1983257180 @default.
- W4310423053 cites W1985409916 @default.
- W4310423053 cites W1987329720 @default.
- W4310423053 cites W1990753499 @default.
- W4310423053 cites W1991294216 @default.
- W4310423053 cites W1994555182 @default.
- W4310423053 cites W1996154142 @default.
- W4310423053 cites W1996593258 @default.
- W4310423053 cites W2006798950 @default.
- W4310423053 cites W2011278616 @default.
- W4310423053 cites W2022567100 @default.
- W4310423053 cites W2028705232 @default.
- W4310423053 cites W2036386225 @default.
- W4310423053 cites W2037029525 @default.
- W4310423053 cites W2037889356 @default.
- W4310423053 cites W2039190163 @default.
- W4310423053 cites W2045232627 @default.
- W4310423053 cites W2047680711 @default.
- W4310423053 cites W2054251296 @default.
- W4310423053 cites W2060977625 @default.
- W4310423053 cites W2063642980 @default.
- W4310423053 cites W2067466613 @default.
- W4310423053 cites W2072552284 @default.
- W4310423053 cites W2072904608 @default.
- W4310423053 cites W2073861762 @default.
- W4310423053 cites W2080779842 @default.
- W4310423053 cites W2087235914 @default.
- W4310423053 cites W2087826027 @default.
- W4310423053 cites W2091362970 @default.
- W4310423053 cites W2092494875 @default.
- W4310423053 cites W2096388312 @default.
- W4310423053 cites W2100569554 @default.
- W4310423053 cites W2101187510 @default.
- W4310423053 cites W2109629598 @default.
- W4310423053 cites W2110457784 @default.
- W4310423053 cites W2117550957 @default.
- W4310423053 cites W2137096994 @default.
- W4310423053 cites W2140594985 @default.
- W4310423053 cites W2151368477 @default.
- W4310423053 cites W2156428325 @default.
- W4310423053 cites W2158426552 @default.
- W4310423053 cites W2158505111 @default.
- W4310423053 cites W2162648242 @default.
- W4310423053 cites W2172150178 @default.
- W4310423053 cites W2189224196 @default.
- W4310423053 cites W2193900514 @default.
- W4310423053 cites W2279400264 @default.
- W4310423053 cites W2286432816 @default.
- W4310423053 cites W2332304649 @default.
- W4310423053 cites W2352134117 @default.
- W4310423053 cites W2417970798 @default.
- W4310423053 cites W2477438706 @default.
- W4310423053 cites W2528073273 @default.
- W4310423053 cites W2552275063 @default.
- W4310423053 cites W2554420058 @default.
- W4310423053 cites W2555813252 @default.
- W4310423053 cites W2560733355 @default.
- W4310423053 cites W2563927047 @default.
- W4310423053 cites W2592450516 @default.
- W4310423053 cites W2608713782 @default.
- W4310423053 cites W2619446543 @default.
- W4310423053 cites W2625992472 @default.
- W4310423053 cites W2626560086 @default.
- W4310423053 cites W2731100712 @default.
- W4310423053 cites W2738150700 @default.
- W4310423053 cites W2778588255 @default.
- W4310423053 cites W2782443304 @default.
- W4310423053 cites W2783481291 @default.
- W4310423053 cites W2788306310 @default.
- W4310423053 cites W2792612728 @default.
- W4310423053 cites W2793786377 @default.
- W4310423053 cites W2800927112 @default.
- W4310423053 cites W2901123377 @default.
- W4310423053 cites W2902494615 @default.
- W4310423053 cites W2911370516 @default.
- W4310423053 cites W2919933215 @default.
- W4310423053 cites W2937904837 @default.
- W4310423053 cites W2952285825 @default.
- W4310423053 cites W2969700256 @default.
- W4310423053 cites W3000255184 @default.
- W4310423053 cites W3017350339 @default.
- W4310423053 cites W3023767191 @default.
- W4310423053 cites W3044074257 @default.
- W4310423053 cites W3046216861 @default.
- W4310423053 cites W3084052865 @default.