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- W4310447955 abstract "Ventriculitis is a severe complication of indwelling neurosurgical devices that is associated with significant morbidity and mortality. The incidence rate of ventriculitis is approximately 10% with external ventricular drains. Obstinately, patients with these indwelling neurosurgical devices are prone to have traditional cerebral spinal fluid parameters that lack sensitivity and specificity in diagnosing nosocomial ventriculitis. In addition, diagnosis can be arduous given that indolent pathogens are commonly implicated. Therefore, diagnosis is difficult but paramount to thwart the morbidity and mortality associated with this infectious condition as well as to reduce the prolonged use of broad-spectrum antibiotics. As we extrapolate from prosthetic joint infections, for which diagnosis can also be challenging, we learn that the use of α-defensins as a diagnostic biomarker for nosocomial ventriculitis may hold promise. Herein, the viewpoint of using α-defensins as a diagnostic biomarker for nosocomial ventriculitis is discussed." @default.
- W4310447955 created "2022-12-10" @default.
- W4310447955 creator A5015368781 @default.
- W4310447955 date "2022-11-30" @default.
- W4310447955 modified "2023-09-26" @default.
- W4310447955 title "Use of α-Defensins to Help Diagnose Nosocomial Ventriculitis" @default.
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- W4310447955 doi "https://doi.org/10.1007/s12028-022-01643-8" @default.
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