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- W4310459042 abstract "Prolonged metabolic stress can lead to severe pathologies. In metabolically challenged primary fibroblasts, we assigned a novel role for the poorly characterized miR-4734 in restricting ATF4 and IRE1-mediated upregulation of a set of proinflammatory cytokines and endoplasmic reticulum stress-associated genes. Conversely, inhibition of this miRNA augmented the expression of those genes. Mechanistically, miR-4734 was found to restrict the expression of the transcriptional activator NF-kappa-B inhibitor zeta (NFKBIZ), which is required for optimal expression of the proinflammatory genes and whose mRNA is targeted directly by miR-4734. Concordantly, overexpression of NFKBIZ compromised the effects of miR-4734, underscoring the importance of this direct targeting. As the effects of miR-4734 were evident under stress but not under basal conditions, it may possess therapeutic utility towards alleviating stress-induced pathologies." @default.
- W4310459042 created "2022-12-10" @default.
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- W4310459042 date "2022-12-11" @default.
- W4310459042 modified "2023-09-26" @default.
- W4310459042 title "<scp>miR</scp>‐4734 conditionally suppresses <scp>ER</scp> stress‐associated proinflammatory responses" @default.
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- W4310459042 doi "https://doi.org/10.1002/1873-3468.14548" @default.
- W4310459042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36445168" @default.
- W4310459042 hasPublicationYear "2022" @default.