FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310459712> ?p ?o ?g. }

• W4310459712 endingPage "71" @default.
• W4310459712 startingPage "61" @default.
• W4310459712 abstract "γδ T cells reside at mucosal and epithelial barriers, and they often accumulate at sites of inflammation, both infectious and autoimmune, as well as in certain tumors. However, progress in understanding their function is considerably hampered by a lack of full understanding of the ligands recognized by TCR-γδ and how expression of these ligands is regulated. We recently developed a soluble human TCR-γδ (Vγ9Vδ1) tetramer from a synovial γδ T cell clone of a Lyme arthritis patient and observed that it stains monocytes activated by Borrelia burgdorferi. Those findings are extended in the current study to further examine the physiological regulation of ligand expression on monocytes. The TCR-γδ ligand is induced by a variety of TLR agonists and requires NF-κB activation. Of particular interest is that ligand expression also requires caspase activation of the inflammasome and is dependent on active metabolism, mitochondrial reactive oxygen species, and activation of gasdermin-D. Consistent with these observations, the TCR-γδ ligand is expressed by a subset of metabolically active CD14+CD16+ monocytes and colocalizes intracellularly with mitochondria. The findings suggest a model in which synovial γδ T cell ligand is a self-antigen whose surface expression is increased by inflammatory conditions and mitochondrial stress." @default.
• W4310459712 created "2022-12-10" @default.
• W4310459712 creator A5019169624 @default.
• W4310459712 creator A5040223603 @default.
• W4310459712 creator A5046186975 @default.
• W4310459712 creator A5058916400 @default.
• W4310459712 creator A5063673623 @default.
• W4310459712 creator A5066461433 @default.
• W4310459712 date "2023-01-01" @default.
• W4310459712 modified "2023-10-02" @default.
• W4310459712 title "Regulation of Synovial γδ T Cell Ligand Expression by Mitochondrial Reactive Oxygen Species and Gasdermin-D" @default.
• W4310459712 cites W1492831386 @default.
• W4310459712 cites W1515528908 @default.
• W4310459712 cites W1538323547 @default.
• W4310459712 cites W1558137520 @default.
• W4310459712 cites W1564175989 @default.
• W4310459712 cites W1566882126 @default.
• W4310459712 cites W1623473717 @default.
• W4310459712 cites W1633034930 @default.
• W4310459712 cites W1635003869 @default.
• W4310459712 cites W1864325817 @default.
• W4310459712 cites W1882905539 @default.
• W4310459712 cites W1920167267 @default.
• W4310459712 cites W1927904403 @default.
• W4310459712 cites W1928730528 @default.
• W4310459712 cites W1972120590 @default.
• W4310459712 cites W1975358757 @default.
• W4310459712 cites W1987208096 @default.
• W4310459712 cites W1991026693 @default.
• W4310459712 cites W2009431476 @default.
• W4310459712 cites W2014012740 @default.
• W4310459712 cites W2029863703 @default.
• W4310459712 cites W2037280768 @default.
• W4310459712 cites W2040154148 @default.
• W4310459712 cites W2042849313 @default.
• W4310459712 cites W2043402384 @default.
• W4310459712 cites W2044748328 @default.
• W4310459712 cites W2060179384 @default.
• W4310459712 cites W2063866466 @default.
• W4310459712 cites W2067773277 @default.
• W4310459712 cites W2070243355 @default.
• W4310459712 cites W2073312795 @default.
• W4310459712 cites W2086486032 @default.
• W4310459712 cites W2093810191 @default.
• W4310459712 cites W2099401468 @default.
• W4310459712 cites W2099616702 @default.
• W4310459712 cites W2114951959 @default.
• W4310459712 cites W2130347663 @default.
• W4310459712 cites W2146175972 @default.
• W4310459712 cites W2148999990 @default.
• W4310459712 cites W2149999204 @default.
• W4310459712 cites W2150433277 @default.
• W4310459712 cites W2152514732 @default.
• W4310459712 cites W2153932008 @default.
• W4310459712 cites W2155071191 @default.
• W4310459712 cites W2156965164 @default.
• W4310459712 cites W2158662692 @default.
• W4310459712 cites W2162375532 @default.
• W4310459712 cites W2166941782 @default.
• W4310459712 cites W2238814703 @default.
• W4310459712 cites W2317391245 @default.
• W4310459712 cites W2340046691 @default.
• W4310459712 cites W2414430764 @default.
• W4310459712 cites W2418806051 @default.
• W4310459712 cites W2462773201 @default.
• W4310459712 cites W2532750272 @default.
• W4310459712 cites W2593763775 @default.
• W4310459712 cites W2754761629 @default.
• W4310459712 cites W2766014141 @default.
• W4310459712 cites W2768102094 @default.
• W4310459712 cites W2784311950 @default.
• W4310459712 cites W2799881184 @default.
• W4310459712 cites W2805135934 @default.
• W4310459712 cites W2808365021 @default.
• W4310459712 cites W2888057265 @default.
• W4310459712 cites W2888168693 @default.
• W4310459712 cites W2888725678 @default.
• W4310459712 cites W2899542051 @default.
• W4310459712 cites W2899591453 @default.
• W4310459712 cites W2921978320 @default.
• W4310459712 cites W2936083981 @default.
• W4310459712 cites W2960044378 @default.
• W4310459712 cites W2972299921 @default.
• W4310459712 cites W2976324456 @default.
• W4310459712 cites W2998735059 @default.
• W4310459712 cites W3012316236 @default.
• W4310459712 cites W3036231704 @default.
• W4310459712 cites W3080259742 @default.
• W4310459712 cites W3106876990 @default.
• W4310459712 cites W3186520869 @default.
• W4310459712 cites W3202981822 @default.
• W4310459712 cites W4285385773 @default.
• W4310459712 cites W4313331972 @default.
• W4310459712 doi "https://doi.org/10.4049/jimmunol.2101166" @default.
• W4310459712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36445376" @default.
• W4310459712 hasPublicationYear "2023" @default.
• W4310459712 type Work @default.
• W4310459712 citedByCount "1" @default.

• next