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- W4310461036 endingPage "77" @default.
- W4310461036 startingPage "57" @default.
- W4310461036 abstract "Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must therefore combat, cooperate with or co-opt the surrounding cells and signalling processes in its microenvironment. It is proposed that an invasive pancreatic ductal adenocarcinoma represents the coordinated evolution of malignant and non-malignant cells and mechanisms that subvert and repurpose normal tissue composition, architecture and physiology to foster tumorigenesis. The complex kinetics and stepwise development of pancreatic cancer suggests that it is governed by a discrete set of organizing rules and principles, and repeated attempts to target specific components within the microenvironment reveal self-regulating mechanisms of resistance. The histopathological and genetic progression models of the transforming ductal epithelium must therefore be considered together with a programme of stromal progression to create a comprehensive picture of pancreatic cancer evolution. Understanding the underlying organizational logic of the tumour to anticipate and pre-empt the almost inevitable compensatory mechanisms will be essential to eradicate the disease." @default.
- W4310461036 created "2022-12-10" @default.
- W4310461036 creator A5013925502 @default.
- W4310461036 date "2022-11-29" @default.
- W4310461036 modified "2023-10-13" @default.
- W4310461036 title "Epithelial and stromal co-evolution and complicity in pancreatic cancer" @default.
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