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- W4310462334 endingPage "1182" @default.
- W4310462334 startingPage "1173" @default.
- W4310462334 abstract "Abstract Immune checkpoint inhibitors (ICI) have significantly improved treatment outcomes for several types of cancer over the past decade, but significant challenges that limit wider effectiveness of current immunotherapies remain to be addressed. Certain “cold” tumor types, such as pancreatic cancer, exhibit very low response rates to ICI due to intrinsically low immunogenicity. In addition, many patients who initially respond to ICI lack a sustained response due to T-cell exhaustion. Several recent studies show that epigenetic modifiers, such as SETDB1 and LSD1, can play critical roles in regulating both tumor cell–intrinsic immunity and T-cell exhaustion. Here, we review the evidence showing that multiple epigenetic regulators silence the expression of endogenous antigens, and their loss induces viral mimicry responses bolstering the response of “cold” tumors to ICI in preclinical models. Similarly, a previously unappreciated role for epigenetic enzymes is emerging in the establishment and maintenance of stem-like T-cell populations that are critical mediators of response to ICI. Targeting the crossroads of epigenetics and immune checkpoint therapy has tremendous potential to improve antitumor immune responses and herald the next generation of sustained responses in immuno-oncology." @default.
- W4310462334 created "2022-12-10" @default.
- W4310462334 creator A5001896694 @default.
- W4310462334 creator A5056977473 @default.
- W4310462334 creator A5076813249 @default.
- W4310462334 date "2022-11-30" @default.
- W4310462334 modified "2023-10-05" @default.
- W4310462334 title "The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy" @default.
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