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- W4310463909 endingPage "1298" @default.
- W4310463909 startingPage "1281" @default.
- W4310463909 abstract "Glioblastoma is the most aggressive type of primary adult brain tumour. The median survival of patients with glioblastoma remains approximately 15 months, and the 5-year survival rate is <10%. Current treatment options are limited, and the standard of care has remained relatively constant since 2011. Over the last decade, a range of different treatment regimens have been investigated with very limited success. Tumour recurrence is almost inevitable with the current treatment strategies, as glioblastoma tumours are highly heterogeneous and invasive. Additionally, another challenging issue facing patients with glioblastoma is how to distinguish between tumour progression and treatment effects, especially when relying on routine diagnostic imaging techniques in the clinic. The specificity of routine imaging for identifying tumour progression early or in a timely manner is poor due to the appearance similarity of post-treatment effects. Here, we concisely describe the current status and challenges in the assessment and early prediction of therapy response and the early detection of tumour progression or recurrence. We also summarize and discuss studies of advanced approaches such as quantitative imaging, liquid biomarker discovery and machine intelligence that hold exceptional potential to aid in the therapy monitoring of this malignancy and early prediction of therapy response, which may decisively transform the conventional detection methods in the era of precision medicine." @default.
- W4310463909 created "2022-12-10" @default.
- W4310463909 creator A5012677271 @default.
- W4310463909 creator A5045792465 @default.
- W4310463909 creator A5055725087 @default.
- W4310463909 creator A5062356470 @default.
- W4310463909 creator A5070309078 @default.
- W4310463909 date "2022-11-29" @default.
- W4310463909 modified "2023-09-27" @default.
- W4310463909 title "Assessment and prediction of glioblastoma therapy response: challenges and opportunities" @default.
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