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- W4310472565 abstract "Abstract Background : The clinicopathological features and endoscopic characteristics under magnifying endoscopy with narrow band imaging (ME-NBI)between early-stage gastric-type differentiated adenocarcinoma (GDA) and intestinal-type differentiated adenocarcinoma (IDA) remain controversial. Methods : Early gastric adenocarcinomas that underwent endoscopic submucosal dissection (ESD) in Nanjing Drum Tower Hospital between August 2017 and August 2021 were included in the present study. GDA cases and IDA cases were selected based on morphology and immunohistochemistry staining of CD10, MUC2, MUC5AC, and MUC6. Clinicopathological data and endoscopic findings in ME-NBI were compared between GDAs and IDAs. Results : The mucin phenotypes of 657 gastric cancers were gastric (n= 307), intestinal (n=109), mixed (n=181) and unclassified (n=60). No significant difference was observed in terms of gender, age, tumor size, gross type, tumor location, background mucosa, lymphatic invasion, and vascular invasion between patients with GDA and IDA. GDA cases were associated with deeper invasion than IDA cases (p=0.007). In ME-NBI, GDAs were more likely to exhibit an intralobular loop patten, whereas IDAs were more likely to exhibit a fine network pattern. In addition, the proportion of none-curative resection in GDAs was significantly higher than that in IDAs (p=0.007). Conclusion : The mucin phenotype of differentiated early gastric adenocarcinoma has clinical significance. GDA was associated with less endoscopically resectability than IDA." @default.
- W4310472565 created "2022-12-10" @default.
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- W4310472565 date "2022-11-30" @default.
- W4310472565 modified "2023-10-18" @default.
- W4310472565 title "Comparison of clinical and pathological features between early-stage gastric-type and intestinal-type differentiated adenocarcinoma: a retrospective study" @default.
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- W4310472565 doi "https://doi.org/10.21203/rs.3.rs-2279318/v1" @default.
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