Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310473608> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4310473608 abstract "We repurposed the metal-binding site of a cupin superfamily protein into the 2-his-1-carboxylate facial triad, which is one of the common motifs in natural non-heme enzymes, to construct artificial metalloenzymes that can catalyze new-to-nature reactions. Cu2+-H52A/H58E variant catalyzed the stereoselective Michael addition reaction and was found to bear a flexible metal-binding site in the high-resolution crystal structure. Furthermore, the H52A/H58E/F104W mutant accommodated a water molecule, which was supported by Glu58 and Trp104 residues via hydrogen bonding, presumably leading to high stereoselectivity. Thus, the 2-his-1-carboxylate facial triad was confirmed to be a versatile and promising metal-binding motif for abiological and canonical biological reactions." @default.
- W4310473608 created "2022-12-10" @default.
- W4310473608 creator A5019482489 @default.
- W4310473608 creator A5022765206 @default.
- W4310473608 creator A5055019116 @default.
- W4310473608 creator A5067370486 @default.
- W4310473608 creator A5074605698 @default.
- W4310473608 creator A5084446866 @default.
- W4310473608 date "2022-11-30" @default.
- W4310473608 modified "2023-09-26" @default.
- W4310473608 title "An Artificial Metallolyase with Pliable 2-His-1-Carboxylate Facial Triad for Stereoselective Michael Addition" @default.
- W4310473608 doi "https://doi.org/10.26434/chemrxiv-2022-5sh4j" @default.
- W4310473608 hasPublicationYear "2022" @default.
- W4310473608 type Work @default.
- W4310473608 citedByCount "0" @default.
- W4310473608 crossrefType "posted-content" @default.
- W4310473608 hasAuthorship W4310473608A5019482489 @default.
- W4310473608 hasAuthorship W4310473608A5022765206 @default.
- W4310473608 hasAuthorship W4310473608A5055019116 @default.
- W4310473608 hasAuthorship W4310473608A5067370486 @default.
- W4310473608 hasAuthorship W4310473608A5074605698 @default.
- W4310473608 hasAuthorship W4310473608A5084446866 @default.
- W4310473608 hasBestOaLocation W43104736081 @default.
- W4310473608 hasConcept C104317684 @default.
- W4310473608 hasConcept C11171543 @default.
- W4310473608 hasConcept C112423150 @default.
- W4310473608 hasConcept C112887158 @default.
- W4310473608 hasConcept C13935069 @default.
- W4310473608 hasConcept C143065580 @default.
- W4310473608 hasConcept C145770059 @default.
- W4310473608 hasConcept C15744967 @default.
- W4310473608 hasConcept C161790260 @default.
- W4310473608 hasConcept C176038584 @default.
- W4310473608 hasConcept C178790620 @default.
- W4310473608 hasConcept C178910836 @default.
- W4310473608 hasConcept C181199279 @default.
- W4310473608 hasConcept C181647583 @default.
- W4310473608 hasConcept C185592680 @default.
- W4310473608 hasConcept C21951064 @default.
- W4310473608 hasConcept C2778074193 @default.
- W4310473608 hasConcept C2779281246 @default.
- W4310473608 hasConcept C32909587 @default.
- W4310473608 hasConcept C41183919 @default.
- W4310473608 hasConcept C55493867 @default.
- W4310473608 hasConcept C71240020 @default.
- W4310473608 hasConceptScore W4310473608C104317684 @default.
- W4310473608 hasConceptScore W4310473608C11171543 @default.
- W4310473608 hasConceptScore W4310473608C112423150 @default.
- W4310473608 hasConceptScore W4310473608C112887158 @default.
- W4310473608 hasConceptScore W4310473608C13935069 @default.
- W4310473608 hasConceptScore W4310473608C143065580 @default.
- W4310473608 hasConceptScore W4310473608C145770059 @default.
- W4310473608 hasConceptScore W4310473608C15744967 @default.
- W4310473608 hasConceptScore W4310473608C161790260 @default.
- W4310473608 hasConceptScore W4310473608C176038584 @default.
- W4310473608 hasConceptScore W4310473608C178790620 @default.
- W4310473608 hasConceptScore W4310473608C178910836 @default.
- W4310473608 hasConceptScore W4310473608C181199279 @default.
- W4310473608 hasConceptScore W4310473608C181647583 @default.
- W4310473608 hasConceptScore W4310473608C185592680 @default.
- W4310473608 hasConceptScore W4310473608C21951064 @default.
- W4310473608 hasConceptScore W4310473608C2778074193 @default.
- W4310473608 hasConceptScore W4310473608C2779281246 @default.
- W4310473608 hasConceptScore W4310473608C32909587 @default.
- W4310473608 hasConceptScore W4310473608C41183919 @default.
- W4310473608 hasConceptScore W4310473608C55493867 @default.
- W4310473608 hasConceptScore W4310473608C71240020 @default.
- W4310473608 hasFunder F4320310657 @default.
- W4310473608 hasFunder F4320327252 @default.
- W4310473608 hasFunder F4320334764 @default.
- W4310473608 hasLocation W43104736081 @default.
- W4310473608 hasOpenAccess W4310473608 @default.
- W4310473608 hasPrimaryLocation W43104736081 @default.
- W4310473608 hasRelatedWork W1965076805 @default.
- W4310473608 hasRelatedWork W2007232769 @default.
- W4310473608 hasRelatedWork W2092482473 @default.
- W4310473608 hasRelatedWork W2113093449 @default.
- W4310473608 hasRelatedWork W2143028632 @default.
- W4310473608 hasRelatedWork W3186955845 @default.
- W4310473608 hasRelatedWork W4238001598 @default.
- W4310473608 hasRelatedWork W4255472055 @default.
- W4310473608 hasRelatedWork W4310473608 @default.
- W4310473608 hasRelatedWork W4324122348 @default.
- W4310473608 isParatext "false" @default.
- W4310473608 isRetracted "false" @default.
- W4310473608 workType "article" @default.