FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310474306> ?p ?o ?g. }

• W4310474306 endingPage "348" @default.
• W4310474306 startingPage "341" @default.
• W4310474306 abstract "Key Points A peroxisome proliferator-activated receptor δ agonist, REN001, ameliorates kidney dysfunction in a mouse model of Alport syndrome. REN001 suppresses glomerular injury and renal fibrosis. REN001 decreases the levels of inflammation- and fibrosis-related proteins. Background Alport syndrome is a genetic kidney disease caused by mutation in any of the COL4A3 , COL4A4 , or COL4A5 genes encoding the type IV collagen α 3, α 4, and α 5 chains. Defects of type IV collagen α 3 α 4 α 5 cause glomerular basement membrane abnormalities and lead to defects in glomerular filtration and ESKD. Treatment with angiotensin-converting enzyme inhibitors (ACEis) dramatically slows disease progression but does not stop progression to renal failure. Therefore, novel therapeutic options with different modes of action from ACEis are needed. Peroxisome proliferator-activated receptor (PPAR) δ agonists have shown renoprotective effects in several acute kidney injury mouse models. In this study, we investigated the effects of a potent and selective PPAR δ agonist, REN001 (formerly HPP593), in a mouse model of Alport syndrome. Methods We administered REN001 from the early stages to the late stages of disease by once daily intraperitoneal injections. Results REN001 treatment halved proteinuria at the late stages of disease in Col4a3 −/− mice. BUN levels were also decreased, and histological and molecular analyses showed that REN001 ameliorated renal inflammation and fibrosis. Conclusions These results indicate that REN001 slows kidney disease progression in Alport mice. REN001 has a different mechanism of action from ACEis, so we, therefore, hypothesize that combining the two treatments may show additive effects to attenuate renal injury and slow progression to renal failure." @default.
• W4310474306 created "2022-12-10" @default.
• W4310474306 creator A5003176828 @default.
• W4310474306 creator A5018829592 @default.
• W4310474306 creator A5038068849 @default.
• W4310474306 date "2023-03-01" @default.
• W4310474306 modified "2023-09-30" @default.
• W4310474306 title "PPARδ Agonism Ameliorates Renal Fibrosis in an Alport Syndrome Mouse Model" @default.
• W4310474306 cites W1965621923 @default.
• W4310474306 cites W1975820359 @default.
• W4310474306 cites W1989038991 @default.
• W4310474306 cites W2031978907 @default.
• W4310474306 cites W2033233404 @default.
• W4310474306 cites W2034618205 @default.
• W4310474306 cites W2043449217 @default.
• W4310474306 cites W2049030581 @default.
• W4310474306 cites W2058691614 @default.
• W4310474306 cites W2066092624 @default.
• W4310474306 cites W2072362233 @default.
• W4310474306 cites W2094683737 @default.
• W4310474306 cites W2102750482 @default.
• W4310474306 cites W2127923616 @default.
• W4310474306 cites W2130430262 @default.
• W4310474306 cites W2165985930 @default.
• W4310474306 cites W2345234619 @default.
• W4310474306 cites W2346347415 @default.
• W4310474306 cites W2461613212 @default.
• W4310474306 cites W2519479884 @default.
• W4310474306 cites W2750153076 @default.
• W4310474306 cites W2766965802 @default.
• W4310474306 cites W2793310729 @default.
• W4310474306 cites W2800723402 @default.
• W4310474306 cites W2802314304 @default.
• W4310474306 cites W2895605837 @default.
• W4310474306 cites W2898491544 @default.
• W4310474306 cites W3151332571 @default.
• W4310474306 cites W4236357753 @default.
• W4310474306 doi "https://doi.org/10.34067/kid.0006662022" @default.
• W4310474306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36657027" @default.
• W4310474306 hasPublicationYear "2023" @default.
• W4310474306 type Work @default.
• W4310474306 citedByCount "1" @default.
• W4310474306 countsByYear W43104743062023 @default.
• W4310474306 crossrefType "journal-article" @default.
• W4310474306 hasAuthorship W4310474306A5003176828 @default.
• W4310474306 hasAuthorship W4310474306A5018829592 @default.
• W4310474306 hasAuthorship W4310474306A5038068849 @default.
• W4310474306 hasBestOaLocation W43104743061 @default.
• W4310474306 hasConcept C126322002 @default.
• W4310474306 hasConcept C134018914 @default.
• W4310474306 hasConcept C159641895 @default.
• W4310474306 hasConcept C2776115139 @default.
• W4310474306 hasConcept C2776908417 @default.
• W4310474306 hasConcept C2777058396 @default.
• W4310474306 hasConcept C2777390665 @default.
• W4310474306 hasConcept C2778653478 @default.
• W4310474306 hasConcept C2779561371 @default.
• W4310474306 hasConcept C2780091579 @default.
• W4310474306 hasConcept C2780368995 @default.
• W4310474306 hasConcept C2780472472 @default.
• W4310474306 hasConcept C2780559512 @default.
• W4310474306 hasConcept C54847362 @default.
• W4310474306 hasConcept C71924100 @default.
• W4310474306 hasConceptScore W4310474306C126322002 @default.
• W4310474306 hasConceptScore W4310474306C134018914 @default.
• W4310474306 hasConceptScore W4310474306C159641895 @default.
• W4310474306 hasConceptScore W4310474306C2776115139 @default.
• W4310474306 hasConceptScore W4310474306C2776908417 @default.
• W4310474306 hasConceptScore W4310474306C2777058396 @default.
• W4310474306 hasConceptScore W4310474306C2777390665 @default.
• W4310474306 hasConceptScore W4310474306C2778653478 @default.
• W4310474306 hasConceptScore W4310474306C2779561371 @default.
• W4310474306 hasConceptScore W4310474306C2780091579 @default.
• W4310474306 hasConceptScore W4310474306C2780368995 @default.
• W4310474306 hasConceptScore W4310474306C2780472472 @default.
• W4310474306 hasConceptScore W4310474306C2780559512 @default.
• W4310474306 hasConceptScore W4310474306C54847362 @default.
• W4310474306 hasConceptScore W4310474306C71924100 @default.
• W4310474306 hasIssue "3" @default.
• W4310474306 hasLocation W43104743061 @default.
• W4310474306 hasLocation W43104743062 @default.
• W4310474306 hasLocation W43104743063 @default.
• W4310474306 hasLocation W43104743064 @default.
• W4310474306 hasOpenAccess W4310474306 @default.
• W4310474306 hasPrimaryLocation W43104743061 @default.
• W4310474306 hasRelatedWork W1994260922 @default.
• W4310474306 hasRelatedWork W2003279470 @default.
• W4310474306 hasRelatedWork W2012043446 @default.
• W4310474306 hasRelatedWork W2020595192 @default.
• W4310474306 hasRelatedWork W2029863361 @default.
• W4310474306 hasRelatedWork W2067470112 @default.
• W4310474306 hasRelatedWork W2067669241 @default.
• W4310474306 hasRelatedWork W2460231899 @default.
• W4310474306 hasRelatedWork W2474838213 @default.
• W4310474306 hasRelatedWork W2946401691 @default.
• W4310474306 hasVolume "4" @default.
• W4310474306 isParatext "false" @default.
• W4310474306 isRetracted "false" @default.

• next