Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310474805> ?p ?o ?g. }
- W4310474805 abstract "The discovery of novel antihelmintic molecules to combat the development and spread of schistosomiasis, a disease caused by several Schistosoma flatworm species, mobilizes significant research efforts worldwide. With a limited number of biochemical assays for measuring the viability of adult worms, the antischistosomicidal activity of molecules is usually evaluated by a microscopic observation of worm mobility and/or integrity upon drug exposure. Even if these phenotypical assays enable multiple parameters analysis, they are often conducted during several days and need to be associated with image-based analysis to minimized subjectivity. We describe here a self-purifying microfluidic system enabling the selection of healthy adult worms and the identification of molecules acting instantly on the parasite. The worms are assayed in a dynamic environment that eliminates unhealthy worms that cannot attach firmly to the chip walls prior to being exposed to the drug. The detachment of the worms is also used as second step readout for identifying active compounds. We have validated this new fluidic screening approach using the two major antihelmintic drugs, praziquantel and artemisinin. The reported dynamic system is simple to produce and to parallelize. Importantly, it enables a quick and sensitive detection of antischistosomal compounds in no more than one hour." @default.
- W4310474805 created "2022-12-10" @default.
- W4310474805 creator A5001469242 @default.
- W4310474805 creator A5025840338 @default.
- W4310474805 creator A5042203473 @default.
- W4310474805 creator A5057066708 @default.
- W4310474805 creator A5065880945 @default.
- W4310474805 creator A5072113587 @default.
- W4310474805 creator A5080967466 @default.
- W4310474805 creator A5085702182 @default.
- W4310474805 creator A5090538372 @default.
- W4310474805 date "2022-11-01" @default.
- W4310474805 modified "2023-10-05" @default.
- W4310474805 title "A self-purifying microfluidic system for identifying drugs acting against adult schistosomes" @default.
- W4310474805 cites W10911041 @default.
- W4310474805 cites W1940986506 @default.
- W4310474805 cites W1967036613 @default.
- W4310474805 cites W1967238845 @default.
- W4310474805 cites W1976656705 @default.
- W4310474805 cites W1982674443 @default.
- W4310474805 cites W1987943737 @default.
- W4310474805 cites W1988867378 @default.
- W4310474805 cites W2006252452 @default.
- W4310474805 cites W2007402574 @default.
- W4310474805 cites W2014103163 @default.
- W4310474805 cites W2038537691 @default.
- W4310474805 cites W2042306674 @default.
- W4310474805 cites W2042361710 @default.
- W4310474805 cites W2055907171 @default.
- W4310474805 cites W2066835202 @default.
- W4310474805 cites W2087486355 @default.
- W4310474805 cites W2093440084 @default.
- W4310474805 cites W2105955725 @default.
- W4310474805 cites W2108483473 @default.
- W4310474805 cites W2124470043 @default.
- W4310474805 cites W2127562516 @default.
- W4310474805 cites W2129062902 @default.
- W4310474805 cites W2158220412 @default.
- W4310474805 cites W2164190707 @default.
- W4310474805 cites W2177715039 @default.
- W4310474805 cites W2280003843 @default.
- W4310474805 cites W2289955976 @default.
- W4310474805 cites W2324958782 @default.
- W4310474805 cites W2397850317 @default.
- W4310474805 cites W241016703 @default.
- W4310474805 cites W2474575800 @default.
- W4310474805 cites W2497850966 @default.
- W4310474805 cites W2519229948 @default.
- W4310474805 cites W2529010156 @default.
- W4310474805 cites W256610153 @default.
- W4310474805 cites W2722512526 @default.
- W4310474805 cites W2742977816 @default.
- W4310474805 cites W2750058540 @default.
- W4310474805 cites W2794589903 @default.
- W4310474805 cites W2892283906 @default.
- W4310474805 cites W2900793673 @default.
- W4310474805 cites W2907241206 @default.
- W4310474805 cites W2911728335 @default.
- W4310474805 cites W2944339573 @default.
- W4310474805 cites W2948628743 @default.
- W4310474805 cites W2962869692 @default.
- W4310474805 cites W2982250586 @default.
- W4310474805 cites W2989563826 @default.
- W4310474805 cites W2995543957 @default.
- W4310474805 cites W3006236243 @default.
- W4310474805 cites W3014373623 @default.
- W4310474805 cites W3033468226 @default.
- W4310474805 cites W3115087947 @default.
- W4310474805 cites W3147606893 @default.
- W4310474805 cites W3160270817 @default.
- W4310474805 cites W3169910019 @default.
- W4310474805 cites W3183627583 @default.
- W4310474805 cites W4200269804 @default.
- W4310474805 cites W4211093028 @default.
- W4310474805 cites W4220791973 @default.
- W4310474805 cites W4223983588 @default.
- W4310474805 cites W4225552085 @default.
- W4310474805 cites W4234390511 @default.
- W4310474805 cites W4310474805 @default.
- W4310474805 doi "https://doi.org/10.1098/rsos.220648" @default.
- W4310474805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36465675" @default.
- W4310474805 hasPublicationYear "2022" @default.
- W4310474805 type Work @default.
- W4310474805 citedByCount "1" @default.
- W4310474805 countsByYear W43104748052022 @default.
- W4310474805 crossrefType "journal-article" @default.
- W4310474805 hasAuthorship W4310474805A5001469242 @default.
- W4310474805 hasAuthorship W4310474805A5025840338 @default.
- W4310474805 hasAuthorship W4310474805A5042203473 @default.
- W4310474805 hasAuthorship W4310474805A5057066708 @default.
- W4310474805 hasAuthorship W4310474805A5065880945 @default.
- W4310474805 hasAuthorship W4310474805A5072113587 @default.
- W4310474805 hasAuthorship W4310474805A5080967466 @default.
- W4310474805 hasAuthorship W4310474805A5085702182 @default.
- W4310474805 hasAuthorship W4310474805A5090538372 @default.
- W4310474805 hasBestOaLocation W43104748054 @default.
- W4310474805 hasConcept C116834253 @default.
- W4310474805 hasConcept C165901193 @default.
- W4310474805 hasConcept C18903297 @default.
- W4310474805 hasConcept C203014093 @default.