FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310477319> ?p ?o ?g. }

• W4310477319 abstract "For all living organisms, the adaptation to outside environments is an essential determinant to survive natural and artificial selections and to sustain the whole ecosystem intact with functional biodiversity. Likewise, cancer cells have similar characteristics that evade not only stresses from the host-internal innate and adaptive immune systems but also those from host-externally administered therapeutic interventions. Such selfish characteristics of cancer cells lead to the formation of cancerous ecosystem with a wide variety of phenotypic heterogeneity, which should be called cancer egosystem from the host point of view. Recently increasing evidence demonstrates that cancer stem cells (CSCs) are responsible for this cancer egosystem by effectively exploiting host inflammatory and hematopoietic cells and thereby reconstructing their own advantageous niches, which may well be a driving force in cancer recurrence. CSCs are further likely to render multiple niches mutually interconnected and cooperating as a network to support back CSCs themselves. Here, we summarize a recently identified iron-replenishing niche network self-organized by glioma CSCs (GSCs) through remote regulation of host myeloid and erythroid lineage cells. GSCs recruit bone marrow (BM)-derived inflammatory monocytes into tumor parenchyma, facilitate their differentiation into macrophages (Mφs) and skew their polarization into pro-tumoral phenotype, i.e., tumor-associated Mφs (TAMs). Meanwhile, GSCs distantly enhance erythropoiesis in host hematopoietic organs like BM and spleen potentially by secreting some soluble mediators that maintain continuous supply of erythrocytes within tumors. In addition, as normal red pulp Mφs (RPMs) under steady state conditions in spleen recycle iron by phagocytosing the aged or damaged erythrocytes (a/dECs) and release it in time of need, TAMs at least in gliomas phagocytose the hemorrhaged erythrocytes within tumors and potentially serve as a source of iron, an important nutrient indispensable to GSC survival and glioma progression. Taken together, these studies provide the substantial evidence that CSCs have a unique strategy to orchestrate multiple niches as an ecosystem that threatens the host living, which in this sense must be an egosystem. Targeting such an adaptive subpopulation of CSCs could achieve drastic disturbance of the CSC niches and subsequent extinction of malignant neoplasms." @default.
• W4310477319 created "2022-12-10" @default.
• W4310477319 creator A5015481457 @default.
• W4310477319 creator A5027403359 @default.
• W4310477319 date "2022-11-30" @default.
• W4310477319 modified "2023-10-14" @default.
• W4310477319 title "Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells" @default.
• W4310477319 cites W1967304777 @default.
• W4310477319 cites W1980485314 @default.
• W4310477319 cites W1988904772 @default.
• W4310477319 cites W1991287908 @default.
• W4310477319 cites W1994915831 @default.
• W4310477319 cites W1995212041 @default.
• W4310477319 cites W1997846723 @default.
• W4310477319 cites W2009886857 @default.
• W4310477319 cites W2022880602 @default.
• W4310477319 cites W2040773741 @default.
• W4310477319 cites W2044455841 @default.
• W4310477319 cites W2051003757 @default.
• W4310477319 cites W2059147394 @default.
• W4310477319 cites W2060551076 @default.
• W4310477319 cites W2062069198 @default.
• W4310477319 cites W2070436269 @default.
• W4310477319 cites W2101082342 @default.
• W4310477319 cites W2103749895 @default.
• W4310477319 cites W2118758371 @default.
• W4310477319 cites W2127823872 @default.
• W4310477319 cites W2136707043 @default.
• W4310477319 cites W2141643004 @default.
• W4310477319 cites W2169011598 @default.
• W4310477319 cites W2208036228 @default.
• W4310477319 cites W2220215167 @default.
• W4310477319 cites W2278315706 @default.
• W4310477319 cites W2586289265 @default.
• W4310477319 cites W2591531756 @default.
• W4310477319 cites W2748329310 @default.
• W4310477319 cites W2790003308 @default.
• W4310477319 cites W2907897113 @default.
• W4310477319 cites W2914193935 @default.
• W4310477319 cites W2915980124 @default.
• W4310477319 cites W2977290732 @default.
• W4310477319 cites W2981443874 @default.
• W4310477319 cites W3019090157 @default.
• W4310477319 cites W3032465961 @default.
• W4310477319 cites W3043725858 @default.
• W4310477319 cites W3047765583 @default.
• W4310477319 cites W3099876323 @default.
• W4310477319 cites W3172039897 @default.
• W4310477319 cites W3174092685 @default.
• W4310477319 cites W3185482622 @default.
• W4310477319 cites W3198841480 @default.
• W4310477319 cites W3203304735 @default.
• W4310477319 cites W3214996566 @default.
• W4310477319 cites W4206630448 @default.
• W4310477319 doi "https://doi.org/10.1186/s41232-022-00240-8" @default.
• W4310477319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36451253" @default.
• W4310477319 hasPublicationYear "2022" @default.
• W4310477319 type Work @default.
• W4310477319 citedByCount "4" @default.
• W4310477319 countsByYear W43104773192023 @default.
• W4310477319 crossrefType "journal-article" @default.
• W4310477319 hasAuthorship W4310477319A5015481457 @default.
• W4310477319 hasAuthorship W4310477319A5027403359 @default.
• W4310477319 hasBestOaLocation W43104773191 @default.
• W4310477319 hasConcept C109159458 @default.
• W4310477319 hasConcept C121608353 @default.
• W4310477319 hasConcept C203014093 @default.
• W4310477319 hasConcept C2780007613 @default.
• W4310477319 hasConcept C28328180 @default.
• W4310477319 hasConcept C502942594 @default.
• W4310477319 hasConcept C54355233 @default.
• W4310477319 hasConcept C55427017 @default.
• W4310477319 hasConcept C86803240 @default.
• W4310477319 hasConcept C8891405 @default.
• W4310477319 hasConcept C95444343 @default.
• W4310477319 hasConcept C96232424 @default.
• W4310477319 hasConceptScore W4310477319C109159458 @default.
• W4310477319 hasConceptScore W4310477319C121608353 @default.
• W4310477319 hasConceptScore W4310477319C203014093 @default.
• W4310477319 hasConceptScore W4310477319C2780007613 @default.
• W4310477319 hasConceptScore W4310477319C28328180 @default.
• W4310477319 hasConceptScore W4310477319C502942594 @default.
• W4310477319 hasConceptScore W4310477319C54355233 @default.
• W4310477319 hasConceptScore W4310477319C55427017 @default.
• W4310477319 hasConceptScore W4310477319C86803240 @default.
• W4310477319 hasConceptScore W4310477319C8891405 @default.
• W4310477319 hasConceptScore W4310477319C95444343 @default.
• W4310477319 hasConceptScore W4310477319C96232424 @default.
• W4310477319 hasFunder F4320311405 @default.
• W4310477319 hasFunder F4320334764 @default.
• W4310477319 hasIssue "1" @default.
• W4310477319 hasLocation W43104773191 @default.
• W4310477319 hasLocation W43104773192 @default.
• W4310477319 hasLocation W43104773193 @default.
• W4310477319 hasOpenAccess W4310477319 @default.
• W4310477319 hasPrimaryLocation W43104773191 @default.
• W4310477319 hasRelatedWork W1978598034 @default.
• W4310477319 hasRelatedWork W2038751426 @default.
• W4310477319 hasRelatedWork W2090080844 @default.
• W4310477319 hasRelatedWork W2140254135 @default.

• next