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- W4310480290 abstract "Hepatoblastoma is a malignant embryonal tumor with multiple differentiation modes and is the clearest liver malignancy in children. However, little is known about genetic and epigenetic events in Hepatoblastoma. Increased research has recently demonstrated, unique genetic and epigenetic events in Hepatoblastoma, providing insights into its origin and precise treatment. Some genetic disorders and congenital factors are associated with the risk of Hepatoblastoma development, such as the Beckwith-Wiedemann syndrome, Familial Adenomatous polyposis, and Hemihypertrophy. Epigenetic modifications such as DNA modifications, histone modifications, and non-coding RNA regulation are also essential in the development of Hepatoblastoma. Herein, we reviewed genetic and epigenetic events in Hepatoblastoma, focusing on the relationship between these events and cancer susceptibility, tumor growth, and prognosis. By deciphering the genetic and epigenetic associations in Hepatoblastoma, tumor pathogenesis can be clarified, and guide the development of new anti-cancer drugs and prevention strategies." @default.
- W4310480290 created "2022-12-10" @default.
- W4310480290 creator A5015358575 @default.
- W4310480290 creator A5028994278 @default.
- W4310480290 creator A5037726749 @default.
- W4310480290 creator A5043994875 @default.
- W4310480290 creator A5047562138 @default.
- W4310480290 creator A5062509066 @default.
- W4310480290 creator A5075014478 @default.
- W4310480290 creator A5084930619 @default.
- W4310480290 date "2022-11-30" @default.
- W4310480290 modified "2023-10-16" @default.
- W4310480290 title "Epigenetics and genetics of hepatoblastoma: Linkage and treatment" @default.
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