Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310480334> ?p ?o ?g. }
- W4310480334 abstract "Introduction Renal podocyte injury, apoptosis and autophagy are involved in the occurrence and development of diabetic nephropathy (DN). Kaempferol (KPF) has the promotion of autophagy and inhibition of apoptosis properties in the development of miscellaneous diseases, but these functions in DN have not yet been elucidated. Methods We used db/db mice to evaluate the protective role of KPF on DN. The anti-DN effect of KPF was evaluated by urine albumin-to-creatinine ratio and pathological changes of kidney tissue. Injury of podocytes was observed through Transmission electron microscopy. Immunofluorescence, Western blot, and Immunohistochemistry were used to detect the protein expression of podocyte-associated molecules, autophagy, and AMPK/mTOR pathway. Results We demonstrated that KPF treatment significantly attenuated diabetes-induced albuminuria and glycolipid metabolism dysfunction. In addition, KPF alleviated mesangial matrix expansion, glomerular basement membrane thickening and loss or fusion of podocytes. Mechanistically, KPF treatment regulated the expression of autophagic proteins (upregulated LC3II, Beclin-1, Atg7 and Atg 5, and downregulated p62/SQSTM1), accompanied by inhibited renal apoptosis (downregulated Caspase 3 and Bax, and upregulated Bcl-2). KPF could significantly regulate the AMPK/mTOR signaling pathways by increasing p-AMPK and decreasing p-mTOR expressions. Discussion In conclusion, KPF might have a protective effect on DN through reduced apoptosis and enhanced podocytes autophagy, which were correlated with regulating AMPK/mTOR pathways." @default.
- W4310480334 created "2022-12-10" @default.
- W4310480334 creator A5010591924 @default.
- W4310480334 creator A5017851336 @default.
- W4310480334 creator A5018603258 @default.
- W4310480334 creator A5020285133 @default.
- W4310480334 creator A5053959355 @default.
- W4310480334 creator A5085650266 @default.
- W4310480334 creator A5085918296 @default.
- W4310480334 creator A5090652507 @default.
- W4310480334 date "2022-11-30" @default.
- W4310480334 modified "2023-10-16" @default.
- W4310480334 title "Kaempferol attenuated diabetic nephropathy by reducing apoptosis and promoting autophagy through AMPK/mTOR pathways" @default.
- W4310480334 cites W1487257968 @default.
- W4310480334 cites W1523693806 @default.
- W4310480334 cites W1784425676 @default.
- W4310480334 cites W1963521777 @default.
- W4310480334 cites W1970637701 @default.
- W4310480334 cites W1977515048 @default.
- W4310480334 cites W1983781911 @default.
- W4310480334 cites W1986477836 @default.
- W4310480334 cites W1989597929 @default.
- W4310480334 cites W1992659717 @default.
- W4310480334 cites W1994823455 @default.
- W4310480334 cites W1996812090 @default.
- W4310480334 cites W2016040396 @default.
- W4310480334 cites W2051719011 @default.
- W4310480334 cites W2064381459 @default.
- W4310480334 cites W2068383276 @default.
- W4310480334 cites W2088254174 @default.
- W4310480334 cites W2107661284 @default.
- W4310480334 cites W2114825009 @default.
- W4310480334 cites W2139243915 @default.
- W4310480334 cites W2146124002 @default.
- W4310480334 cites W2149332763 @default.
- W4310480334 cites W2179291431 @default.
- W4310480334 cites W2497334009 @default.
- W4310480334 cites W2550324269 @default.
- W4310480334 cites W2590746002 @default.
- W4310480334 cites W2594651069 @default.
- W4310480334 cites W2751019535 @default.
- W4310480334 cites W2769399671 @default.
- W4310480334 cites W2790620225 @default.
- W4310480334 cites W2885179151 @default.
- W4310480334 cites W2889925472 @default.
- W4310480334 cites W2900814623 @default.
- W4310480334 cites W2914898147 @default.
- W4310480334 cites W2974173728 @default.
- W4310480334 cites W2991422643 @default.
- W4310480334 cites W3009985618 @default.
- W4310480334 cites W3025378854 @default.
- W4310480334 cites W3043225044 @default.
- W4310480334 cites W3091940245 @default.
- W4310480334 cites W3095864827 @default.
- W4310480334 cites W3129537855 @default.
- W4310480334 cites W3188803792 @default.
- W4310480334 cites W3210287731 @default.
- W4310480334 cites W4200517045 @default.
- W4310480334 cites W4229014725 @default.
- W4310480334 doi "https://doi.org/10.3389/fmed.2022.986825" @default.
- W4310480334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36530875" @default.
- W4310480334 hasPublicationYear "2022" @default.
- W4310480334 type Work @default.
- W4310480334 citedByCount "3" @default.
- W4310480334 countsByYear W43104803342023 @default.
- W4310480334 crossrefType "journal-article" @default.
- W4310480334 hasAuthorship W4310480334A5010591924 @default.
- W4310480334 hasAuthorship W4310480334A5017851336 @default.
- W4310480334 hasAuthorship W4310480334A5018603258 @default.
- W4310480334 hasAuthorship W4310480334A5020285133 @default.
- W4310480334 hasAuthorship W4310480334A5053959355 @default.
- W4310480334 hasAuthorship W4310480334A5085650266 @default.
- W4310480334 hasAuthorship W4310480334A5085918296 @default.
- W4310480334 hasAuthorship W4310480334A5090652507 @default.
- W4310480334 hasBestOaLocation W43104803341 @default.
- W4310480334 hasConcept C104317684 @default.
- W4310480334 hasConcept C126322002 @default.
- W4310480334 hasConcept C127561419 @default.
- W4310480334 hasConcept C184235292 @default.
- W4310480334 hasConcept C185592680 @default.
- W4310480334 hasConcept C190283241 @default.
- W4310480334 hasConcept C203522944 @default.
- W4310480334 hasConcept C2776855237 @default.
- W4310480334 hasConcept C2777146197 @default.
- W4310480334 hasConcept C2779561371 @default.
- W4310480334 hasConcept C2779922275 @default.
- W4310480334 hasConcept C2780091579 @default.
- W4310480334 hasConcept C2780124434 @default.
- W4310480334 hasConcept C2780819817 @default.
- W4310480334 hasConcept C502942594 @default.
- W4310480334 hasConcept C55493867 @default.
- W4310480334 hasConcept C62478195 @default.
- W4310480334 hasConcept C71924100 @default.
- W4310480334 hasConcept C86554907 @default.
- W4310480334 hasConcept C86803240 @default.
- W4310480334 hasConcept C95444343 @default.
- W4310480334 hasConcept C97029542 @default.
- W4310480334 hasConceptScore W4310480334C104317684 @default.
- W4310480334 hasConceptScore W4310480334C126322002 @default.
- W4310480334 hasConceptScore W4310480334C127561419 @default.