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- W4310480943 abstract "Peripheral neuropathy is associated with chronic debilitating pain and is difficult to treat. In this regard, the development of cell therapy of neuropathic pain using adipose-derived mesenchymal stem cells (MSCs) seems to be relevant. The work was devoted to study the impact of adipose-derived allogeneic MSC transplantation on nociceptive reactions in response to mechanical and thermal stimuli and gait parameters in rats with sciatic nerve injury. It is found that a single local injection of MSCs at a dose of 1·10 6 cells/kg eliminates axotomy-induced mechanical and thermal hyperalgesia on the 14th day after transplantation, contributes to the recovery of the sciatic functional index and the dynamic gait parameters on the 7th day after transplantation, and prevents the development of gait disturbances in the long-term period." @default.
- W4310480943 created "2022-12-10" @default.
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- W4310480943 date "2022-11-29" @default.
- W4310480943 modified "2023-10-06" @default.
- W4310480943 title "Impact of adipose-derived allogeneic mesenchymal stem cell transplantation on nociceptive reactions and gait parameters in rats with experimental peripheral neuropathy" @default.
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- W4310480943 doi "https://doi.org/10.29235/1814-6023-2022-19-4-404-412" @default.
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