Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310482344> ?p ?o ?g. }
- W4310482344 abstract "The element, Selenium (Se), has an essential nutritive and biological role as a trace mineral known primarily for its vital antioxidant functions as a constituent of the selenoenzyme, glutathione peroxidase. However, Se also has a much more global biological impact beyond antioxidant function. The objective of this review is to present an overview of prior research on the extra-antioxidant effects of Se with a key focus on skeletal muscle mitochondrial energetics. Cognizance of these additional functions of Se is requisite when formulating and recommending dietary supplementation of Se in humans or animals. Chief amongst its myriad of biological contributions, Se influences mitochondrial capacity and function and, subsequently, muscular health. Dietary Se supplementation has been shown to increase skeletal muscle mitochondrial volume density and within some cell lines, Se treatment increases mitochondrial biogenesis and respiratory capacity. In addition, the selenoproteins H, N, W, and O and deiodinases exhibit varying effects on mitochondrial and/or skeletal muscle function. Selenoprotein H enhances mitochondrial biogenesis whereas selenoproteins N and W appear to influence muscle calcium homeostasis which impacts mitochondrial function. Moreover, selenoprotein O's intramitochondrial residence facilitates Se's redox function. Deiodinases regulate thyroid hormone activation which impacts muscle cell regeneration, metabolism, and reactive oxygen species production. Although the precise relationships between dietary Se and skeletal muscle mitochondria remain unclear, previous research constitutes a firm foundation that portends promising new discoveries by future investigations." @default.
- W4310482344 created "2022-12-10" @default.
- W4310482344 creator A5006201975 @default.
- W4310482344 creator A5015980090 @default.
- W4310482344 creator A5035547392 @default.
- W4310482344 date "2022-12-01" @default.
- W4310482344 modified "2023-09-26" @default.
- W4310482344 title "Beyond antioxidants: Selenium and skeletal muscle mitochondria" @default.
- W4310482344 cites W1489953107 @default.
- W4310482344 cites W1524273338 @default.
- W4310482344 cites W1544412109 @default.
- W4310482344 cites W1550391832 @default.
- W4310482344 cites W1580746914 @default.
- W4310482344 cites W1595570385 @default.
- W4310482344 cites W1604186653 @default.
- W4310482344 cites W1665938856 @default.
- W4310482344 cites W1756031092 @default.
- W4310482344 cites W181688216 @default.
- W4310482344 cites W1854373490 @default.
- W4310482344 cites W1965195943 @default.
- W4310482344 cites W1965722126 @default.
- W4310482344 cites W1968197570 @default.
- W4310482344 cites W1971082641 @default.
- W4310482344 cites W1971347277 @default.
- W4310482344 cites W1974502663 @default.
- W4310482344 cites W1981364887 @default.
- W4310482344 cites W1981521306 @default.
- W4310482344 cites W1981899788 @default.
- W4310482344 cites W1981948323 @default.
- W4310482344 cites W1985579353 @default.
- W4310482344 cites W1996821192 @default.
- W4310482344 cites W2005308044 @default.
- W4310482344 cites W2007091221 @default.
- W4310482344 cites W2007629381 @default.
- W4310482344 cites W2012440305 @default.
- W4310482344 cites W2019113146 @default.
- W4310482344 cites W2027933081 @default.
- W4310482344 cites W2028999784 @default.
- W4310482344 cites W2038496059 @default.
- W4310482344 cites W2048860529 @default.
- W4310482344 cites W2050938499 @default.
- W4310482344 cites W2051066498 @default.
- W4310482344 cites W2052248930 @default.
- W4310482344 cites W2070742508 @default.
- W4310482344 cites W2070805734 @default.
- W4310482344 cites W2071631797 @default.
- W4310482344 cites W2075690495 @default.
- W4310482344 cites W2080536099 @default.
- W4310482344 cites W2084292792 @default.
- W4310482344 cites W2084889190 @default.
- W4310482344 cites W2089326429 @default.
- W4310482344 cites W2095535075 @default.
- W4310482344 cites W2100121792 @default.
- W4310482344 cites W2105404724 @default.
- W4310482344 cites W2115460871 @default.
- W4310482344 cites W2117692658 @default.
- W4310482344 cites W2142718693 @default.
- W4310482344 cites W2143588920 @default.
- W4310482344 cites W2145330934 @default.
- W4310482344 cites W2154681278 @default.
- W4310482344 cites W2155446034 @default.
- W4310482344 cites W2156967886 @default.
- W4310482344 cites W2168433858 @default.
- W4310482344 cites W2170380830 @default.
- W4310482344 cites W2332100992 @default.
- W4310482344 cites W2416847719 @default.
- W4310482344 cites W2517276816 @default.
- W4310482344 cites W2597458850 @default.
- W4310482344 cites W2623804275 @default.
- W4310482344 cites W2626582561 @default.
- W4310482344 cites W2746503859 @default.
- W4310482344 cites W2766082649 @default.
- W4310482344 cites W2892393119 @default.
- W4310482344 cites W2903619454 @default.
- W4310482344 cites W2923472698 @default.
- W4310482344 cites W2946144257 @default.
- W4310482344 cites W3021207952 @default.
- W4310482344 cites W3040839896 @default.
- W4310482344 cites W3054257600 @default.
- W4310482344 cites W4225884744 @default.
- W4310482344 cites W4231624257 @default.
- W4310482344 cites W4254959781 @default.
- W4310482344 cites W4256260252 @default.
- W4310482344 cites W4282832050 @default.
- W4310482344 cites W4289100958 @default.
- W4310482344 cites W44747780 @default.
- W4310482344 doi "https://doi.org/10.3389/fvets.2022.1011159" @default.
- W4310482344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36532343" @default.
- W4310482344 hasPublicationYear "2022" @default.
- W4310482344 type Work @default.
- W4310482344 citedByCount "4" @default.
- W4310482344 countsByYear W43104823442023 @default.
- W4310482344 crossrefType "journal-article" @default.
- W4310482344 hasAuthorship W4310482344A5006201975 @default.
- W4310482344 hasAuthorship W4310482344A5015980090 @default.
- W4310482344 hasAuthorship W4310482344A5035547392 @default.
- W4310482344 hasBestOaLocation W43104823441 @default.
- W4310482344 hasConcept C134018914 @default.
- W4310482344 hasConcept C185592680 @default.
- W4310482344 hasConcept C2775838275 @default.