FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310484996> ?p ?o ?g. }

• W4310484996 endingPage "15060" @default.
• W4310484996 startingPage "15060" @default.
• W4310484996 abstract "The peptide hormone insulin-like 3 (INSL3) is produced almost exclusively by Leydig cells of the male gonad. INSL3 has several functions such as fetal testis descent and bone metabolism in adults. Insl3 gene expression in Leydig cells is not hormonally regulated but rather is constitutively expressed. The regulatory region of the Insl3 gene has been described in various species; moreover, functional studies have revealed that the Insl3 promoter is regulated by various transcription factors that include the nuclear receptors AR, NUR77, COUP-TFII, LRH1, and SF1, as well as the Krüppel-like factor KLF6. However, these transcription factors are also found in several tissues that do not express Insl3, indicating that other, yet unidentified factors, must be involved to drive Insl3 expression specifically in Leydig cells. Through a fine functional promoter analysis, we have identified a 35-bp region that is responsible for conferring 70% of the activity of the mouse Insl3 promoter in Leydig cells. All tri- and dinucleotide mutations introduced dramatically reduced Insl3 promoter activity, indicating that the entire 35-bp sequence is required. Nuclear proteins from MA-10 Leydig cells bound specifically to the 35-bp region. The 35-bp sequence contains GC- and GA-rich motifs as well as potential binding elements for members of the CREB, C/EBP, AP1, AP2, and NF-κB families. The Insl3 promoter was indeed activated 2-fold by NF-κB p50 but not by other transcription factors tested. These results help to further define the regulation of Insl3 gene transcription in Leydig cells." @default.
• W4310484996 created "2022-12-11" @default.
• W4310484996 creator A5018099628 @default.
• W4310484996 creator A5026646966 @default.
• W4310484996 creator A5061587214 @default.
• W4310484996 creator A5089185756 @default.
• W4310484996 date "2022-12-01" @default.
• W4310484996 modified "2023-09-27" @default.
• W4310484996 title "A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells" @default.
• W4310484996 cites W1559988016 @default.
• W4310484996 cites W1566427805 @default.
• W4310484996 cites W1604970632 @default.
• W4310484996 cites W1610204701 @default.
• W4310484996 cites W1973252220 @default.
• W4310484996 cites W1974926090 @default.
• W4310484996 cites W1976119146 @default.
• W4310484996 cites W1978387202 @default.
• W4310484996 cites W1980093972 @default.
• W4310484996 cites W1982417024 @default.
• W4310484996 cites W1985937024 @default.
• W4310484996 cites W1987984806 @default.
• W4310484996 cites W1988495226 @default.
• W4310484996 cites W1990307219 @default.
• W4310484996 cites W1994990062 @default.
• W4310484996 cites W2005556601 @default.
• W4310484996 cites W2010121586 @default.
• W4310484996 cites W2014379407 @default.
• W4310484996 cites W2016730049 @default.
• W4310484996 cites W2019611093 @default.
• W4310484996 cites W2024210568 @default.
• W4310484996 cites W2027451069 @default.
• W4310484996 cites W2030621682 @default.
• W4310484996 cites W2031447271 @default.
• W4310484996 cites W2031720983 @default.
• W4310484996 cites W2032516318 @default.
• W4310484996 cites W2032652749 @default.
• W4310484996 cites W2042448138 @default.
• W4310484996 cites W2049566660 @default.
• W4310484996 cites W2053099768 @default.
• W4310484996 cites W2063756071 @default.
• W4310484996 cites W2066298559 @default.
• W4310484996 cites W2068471276 @default.
• W4310484996 cites W2069012485 @default.
• W4310484996 cites W2074069949 @default.
• W4310484996 cites W2075363163 @default.
• W4310484996 cites W2079150282 @default.
• W4310484996 cites W2079898330 @default.
• W4310484996 cites W2081650299 @default.
• W4310484996 cites W2087419420 @default.
• W4310484996 cites W2088359631 @default.
• W4310484996 cites W2088968639 @default.
• W4310484996 cites W2097329828 @default.
• W4310484996 cites W2100531443 @default.
• W4310484996 cites W2105577099 @default.
• W4310484996 cites W2105695731 @default.
• W4310484996 cites W2105715705 @default.
• W4310484996 cites W2105857830 @default.
• W4310484996 cites W2109440467 @default.
• W4310484996 cites W2116102471 @default.
• W4310484996 cites W2126460557 @default.
• W4310484996 cites W2132581949 @default.
• W4310484996 cites W2133704602 @default.
• W4310484996 cites W2134331077 @default.
• W4310484996 cites W2139493371 @default.
• W4310484996 cites W2139767645 @default.
• W4310484996 cites W2140166139 @default.
• W4310484996 cites W2145820822 @default.
• W4310484996 cites W2158939789 @default.
• W4310484996 cites W2161121464 @default.
• W4310484996 cites W2162264071 @default.
• W4310484996 cites W2167099085 @default.
• W4310484996 cites W2170005346 @default.
• W4310484996 cites W2170552750 @default.
• W4310484996 cites W2171050441 @default.
• W4310484996 cites W2273256317 @default.
• W4310484996 cites W2316567643 @default.
• W4310484996 cites W2604789847 @default.
• W4310484996 cites W2787259202 @default.
• W4310484996 cites W2792778499 @default.
• W4310484996 cites W2892109034 @default.
• W4310484996 cites W2893030563 @default.
• W4310484996 cites W2954868346 @default.
• W4310484996 cites W2978254870 @default.
• W4310484996 cites W3040994366 @default.
• W4310484996 cites W3202852931 @default.
• W4310484996 cites W3210038054 @default.
• W4310484996 cites W4200475671 @default.
• W4310484996 cites W4223552703 @default.
• W4310484996 cites W4223590012 @default.
• W4310484996 cites W4281885772 @default.
• W4310484996 cites W4307945778 @default.
• W4310484996 cites W651853395 @default.
• W4310484996 doi "https://doi.org/10.3390/ijms232315060" @default.
• W4310484996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36499388" @default.
• W4310484996 hasPublicationYear "2022" @default.
• W4310484996 type Work @default.
• W4310484996 citedByCount "1" @default.
• W4310484996 countsByYear W43104849962023 @default.

• next