Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310493720> ?p ?o ?g. }
- W4310493720 abstract "Recent characterization of the obligate episymbiont Saccharibacteria (TM7) belonging to the candidate phyla radiation (CPR) has expanded the extent of microbial diversity. However, the episymbiotic lifestyle of TM7 is still underexploited due to the deficiency of cultivated representatives. Here, we describe gene-targeted TM7 cultivation guided by repurposing epicPCR (emulsion, paired isolation, and concatenation PCR) to capture in situ TM7‒host associations. Using this method, we obtained a novel Saccharibacteria isolate TM7i and its host Leucobacter aridicollis J1 from Cicadae Periostracum, the castoff shell of cicada. Genomic analyses and microscopic characterizations revealed that TM7i could bind to J1 through twitching-like motility mediated by type IV pili (T4P). We further showed that the inhibition of T4P extrusion suppressed the motility and host adherence of TM7i, resulting in its reduced growth. However, the inactivation of T4P had little effect on the growth of TM7i that had already adhered to J1, suggesting the essential role of T4P in host recognition by TM7i. By capturing CPR‒host association and elaborating the T4P-dependent episymbiotic association mechanism, our studies shed light on the distinct yet widespread lifestyle of CPR bacteria." @default.
- W4310493720 created "2022-12-11" @default.
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- W4310493720 date "2022-12-01" @default.
- W4310493720 modified "2023-10-14" @default.
- W4310493720 title "Type IV pili trigger episymbiotic association of Saccharibacteria with its bacterial host" @default.
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- W4310493720 doi "https://doi.org/10.1073/pnas.2215990119" @default.
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