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• W4310494088 abstract "DMD-9 is a Caenorhabditis elegans Doublesex/MAB-3 Domain transcription factor (TF) of unknown function. Single-cell transcriptomics has revealed that dmd-9 is highly expressed in specific head sensory neurons, with lower levels detected in non-neuronal tissues (uterine cells and sperm). Here, we characterized endogenous dmd-9 expression and function in hermaphrodites and males to identify potential sexually dimorphic roles. In addition, we dissected the trans- and cis-regulatory mechanisms that control DMD-9 expression in neurons. Our results show that of the 22 neuronal cell fate reporters we assessed in DMD-9-expressing neurons, only the neuropeptide-encoding flp-19 gene is cell-autonomously regulated by DMD-9. Further, we did not identify defects in behaviors mediated by DMD-9 expressing neurons in dmd-9 mutants. We found that dmd-9 expression in neurons is regulated by 4 neuronal fate regulatory TFs: ETS-5, EGL-13, CHE-1, and TTX-1. In conclusion, our study characterized the DMD-9 expression pattern and regulatory logic for its control. The lack of detectable phenotypes in dmd-9 mutant animals suggests that other proteins compensate for its loss." @default.
• W4310494088 created "2022-12-11" @default.
• W4310494088 creator A5006511186 @default.
• W4310494088 creator A5030284071 @default.
• W4310494088 date "2022-12-01" @default.
• W4310494088 modified "2023-10-14" @default.
• W4310494088 title "Characterization of the Doublesex/MAB-3 transcription factor DMD-9 in <i>Caenorhabditis elegans</i>" @default.
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• W4310494088 doi "https://doi.org/10.1093/g3journal/jkac305" @default.
• W4310494088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36454093" @default.
• W4310494088 hasPublicationYear "2022" @default.
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