FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310497682> ?p ?o ?g. }

• W4310497682 abstract "Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma—namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors (ICIs), and targeted immunotherapies—may offer an improved survival benefit by overcoming limitations associated with any individual therapy. Still, optimal combination, order, and timing of administration remains under investigation. Here, we measure how MEK inhibition (MEKi) alters anti-tumor immunity by utilizing quantitative immunopeptidomics to profile changes in the peptide major histocompatibility molecules (pMHC) repertoire. These data reveal a collection of tumor antigens whose presentation levels are selectively augmented following therapy, including several epitopes present at over 1,000 copies per cell. We leveraged the tunable abundance of MEKi-modulated antigens by targeting four epitopes with pMHC-specific T cell engagers and antibody drug conjugates, enhancing cell killing in tumor cells following MEK inhibition. These results highlight drug treatment as a means to enhance immunotherapy efficacy by targeting specific upregulated pMHCs and provide a methodological framework for identifying, quantifying, and therapeutically targeting additional epitopes of interest." @default.
• W4310497682 created "2022-12-11" @default.
• W4310497682 creator A5003376555 @default.
• W4310497682 creator A5007476220 @default.
• W4310497682 creator A5014963329 @default.
• W4310497682 creator A5032078195 @default.
• W4310497682 creator A5052851903 @default.
• W4310497682 creator A5055441920 @default.
• W4310497682 creator A5063430862 @default.
• W4310497682 creator A5076061881 @default.
• W4310497682 creator A5079058150 @default.
• W4310497682 date "2022-12-01" @default.
• W4310497682 modified "2023-09-26" @default.
• W4310497682 title "MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas" @default.
• W4310497682 cites W1804597912 @default.
• W4310497682 cites W1950829641 @default.
• W4310497682 cites W1967135832 @default.
• W4310497682 cites W1967425011 @default.
• W4310497682 cites W1969124154 @default.
• W4310497682 cites W1983143892 @default.
• W4310497682 cites W1988379285 @default.
• W4310497682 cites W2002755395 @default.
• W4310497682 cites W2014275356 @default.
• W4310497682 cites W2018093205 @default.
• W4310497682 cites W2050302632 @default.
• W4310497682 cites W2070748533 @default.
• W4310497682 cites W2071255079 @default.
• W4310497682 cites W2080582498 @default.
• W4310497682 cites W2094481139 @default.
• W4310497682 cites W2099044540 @default.
• W4310497682 cites W2114903025 @default.
• W4310497682 cites W2116376943 @default.
• W4310497682 cites W2119324245 @default.
• W4310497682 cites W2120508717 @default.
• W4310497682 cites W2123361236 @default.
• W4310497682 cites W2130410032 @default.
• W4310497682 cites W2136474966 @default.
• W4310497682 cites W2144242764 @default.
• W4310497682 cites W2155364136 @default.
• W4310497682 cites W2163188200 @default.
• W4310497682 cites W2166662937 @default.
• W4310497682 cites W2213204442 @default.
• W4310497682 cites W2301994020 @default.
• W4310497682 cites W2334240824 @default.
• W4310497682 cites W2509527114 @default.
• W4310497682 cites W2526479644 @default.
• W4310497682 cites W2572174216 @default.
• W4310497682 cites W2594485226 @default.
• W4310497682 cites W2594529508 @default.
• W4310497682 cites W2620403292 @default.
• W4310497682 cites W2743762084 @default.
• W4310497682 cites W2750328162 @default.
• W4310497682 cites W2804822184 @default.
• W4310497682 cites W2808619920 @default.
• W4310497682 cites W2887759341 @default.
• W4310497682 cites W2888349826 @default.
• W4310497682 cites W2896600825 @default.
• W4310497682 cites W2898389621 @default.
• W4310497682 cites W2902716259 @default.
• W4310497682 cites W2917094217 @default.
• W4310497682 cites W2932851203 @default.
• W4310497682 cites W2943998306 @default.
• W4310497682 cites W2945590213 @default.
• W4310497682 cites W2948155539 @default.
• W4310497682 cites W2948740360 @default.
• W4310497682 cites W2952596195 @default.
• W4310497682 cites W3031716951 @default.
• W4310497682 cites W3072109384 @default.
• W4310497682 cites W3112811149 @default.
• W4310497682 cites W3134236823 @default.
• W4310497682 cites W3134794297 @default.
• W4310497682 cites W3159381651 @default.
• W4310497682 cites W3196945974 @default.
• W4310497682 cites W3207689502 @default.
• W4310497682 cites W3209374438 @default.
• W4310497682 cites W4205309242 @default.
• W4310497682 doi "https://doi.org/10.1073/pnas.2208900119" @default.
• W4310497682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36454758" @default.
• W4310497682 hasPublicationYear "2022" @default.
• W4310497682 type Work @default.
• W4310497682 citedByCount "3" @default.
• W4310497682 countsByYear W43104976822023 @default.
• W4310497682 crossrefType "journal-article" @default.
• W4310497682 hasAuthorship W4310497682A5003376555 @default.
• W4310497682 hasAuthorship W4310497682A5007476220 @default.
• W4310497682 hasAuthorship W4310497682A5014963329 @default.
• W4310497682 hasAuthorship W4310497682A5032078195 @default.
• W4310497682 hasAuthorship W4310497682A5052851903 @default.
• W4310497682 hasAuthorship W4310497682A5055441920 @default.
• W4310497682 hasAuthorship W4310497682A5063430862 @default.
• W4310497682 hasAuthorship W4310497682A5076061881 @default.
• W4310497682 hasAuthorship W4310497682A5079058150 @default.
• W4310497682 hasBestOaLocation W43104976821 @default.
• W4310497682 hasConcept C104317684 @default.
• W4310497682 hasConcept C147483822 @default.
• W4310497682 hasConcept C195616568 @default.
• W4310497682 hasConcept C203014093 @default.
• W4310497682 hasConcept C207936829 @default.
• W4310497682 hasConcept C21790070 @default.
• W4310497682 hasConcept C2776090121 @default.

• next