FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310506605> ?p ?o ?g. }

• W4310506605 endingPage "53" @default.
• W4310506605 startingPage "41" @default.
• W4310506605 abstract "Although copper is an essential trace element for cell function and viability, its excess can lead to protein oxidation, DNA cleavage, and ultimate cell damage. Cells have established a variety of regulatory mechanisms to ensure copper ion homeostasis. In Saccharomyces cerevisiae, copper sensing and response to copper deficiency are regulated by the transcription factor Mac1. Our group has previously reported that in addition to copper, several chromatin proteins modulate Mac1 functionality. In this study, based on a synthetic growth deficiency phenotype, we showed that the Cu/Zn superoxide dismutase Sod1 plays an important role in Mac1 transcriptional activity, in unchallenged nutrient-rich growth conditions. Sod1 is a multipotent cytoplasmic and mitochondrial enzyme, whose main known function is to detoxify the cell from superoxide ions. It has been previously reported that Sod1 also enters the nucleus and affects the transcription of several genes, some of which are involved in copper homeostasis under Cu-depleted (Wood and Thiele in J Biol Chem 284:404-413, 2009) or only under specific oxidative stress conditions (Dong et al. Mol Cell Biol 33:4041-4050, 2013; Tsang et al. Nar Commun 8:3446, 2014). We have shown that Sod1 physically interacts with Mac1 transcription factor and is important for the transactivation as well as its DNA-binding activities. On the other hand, a constitutively active mutant of Mac1 is not affected functionally by the Sod1 ablation, pointing out that Sod1 contributes to the maintenance of the copper-unchelated state of Mac1. In conclusion, we showed that Sod1-Mac1 interaction is vital for Mac1 functionality, regardless of copper medium deficiency, in unchallenged growth conditions, and we suggest that Sod1 enzymatic activity may modify the redox state of the cysteine-rich motifs in the Mac1 DNA-binding and transactivation domains." @default.
• W4310506605 created "2022-12-11" @default.
• W4310506605 creator A5037610217 @default.
• W4310506605 creator A5039378102 @default.
• W4310506605 creator A5042170489 @default.
• W4310506605 creator A5045927822 @default.
• W4310506605 date "2022-12-01" @default.
• W4310506605 modified "2023-09-30" @default.
• W4310506605 title "The essential liaison of two copper proteins: the Cu-sensing transcription factor Mac1 and the Cu/Zn superoxide dismutase Sod1 in Saccharomyces cerevisiae" @default.
• W4310506605 cites W1489286950 @default.
• W4310506605 cites W1573826674 @default.
• W4310506605 cites W1608856014 @default.
• W4310506605 cites W168124872 @default.
• W4310506605 cites W1759734542 @default.
• W4310506605 cites W1903792504 @default.
• W4310506605 cites W1979535442 @default.
• W4310506605 cites W1991039509 @default.
• W4310506605 cites W1993408262 @default.
• W4310506605 cites W1995491627 @default.
• W4310506605 cites W1995530354 @default.
• W4310506605 cites W1997313112 @default.
• W4310506605 cites W2001977932 @default.
• W4310506605 cites W2007632640 @default.
• W4310506605 cites W2010077871 @default.
• W4310506605 cites W2010103693 @default.
• W4310506605 cites W2025441055 @default.
• W4310506605 cites W2029589204 @default.
• W4310506605 cites W2030974529 @default.
• W4310506605 cites W2037434205 @default.
• W4310506605 cites W2041100467 @default.
• W4310506605 cites W2041995080 @default.
• W4310506605 cites W2043179564 @default.
• W4310506605 cites W2049849193 @default.
• W4310506605 cites W2050280746 @default.
• W4310506605 cites W2050463283 @default.
• W4310506605 cites W2055855305 @default.
• W4310506605 cites W2059620285 @default.
• W4310506605 cites W2060344182 @default.
• W4310506605 cites W2072874326 @default.
• W4310506605 cites W2076609405 @default.
• W4310506605 cites W2078349645 @default.
• W4310506605 cites W2079310705 @default.
• W4310506605 cites W2080390432 @default.
• W4310506605 cites W2081373204 @default.
• W4310506605 cites W2084942769 @default.
• W4310506605 cites W2085994989 @default.
• W4310506605 cites W2086390365 @default.
• W4310506605 cites W2089042385 @default.
• W4310506605 cites W2090201814 @default.
• W4310506605 cites W2093477805 @default.
• W4310506605 cites W2096303918 @default.
• W4310506605 cites W2096752472 @default.
• W4310506605 cites W2100625171 @default.
• W4310506605 cites W2106290468 @default.
• W4310506605 cites W2107071733 @default.
• W4310506605 cites W2113131102 @default.
• W4310506605 cites W2115708356 @default.
• W4310506605 cites W2118159036 @default.
• W4310506605 cites W2122749282 @default.
• W4310506605 cites W2125037450 @default.
• W4310506605 cites W2129299386 @default.
• W4310506605 cites W2132532293 @default.
• W4310506605 cites W2133657440 @default.
• W4310506605 cites W2136728068 @default.
• W4310506605 cites W2139655534 @default.
• W4310506605 cites W2140561339 @default.
• W4310506605 cites W2152231771 @default.
• W4310506605 cites W2159294156 @default.
• W4310506605 cites W2164935229 @default.
• W4310506605 cites W2593997122 @default.
• W4310506605 cites W2617570220 @default.
• W4310506605 cites W2802369762 @default.
• W4310506605 cites W2892367242 @default.
• W4310506605 cites W2903653109 @default.
• W4310506605 cites W2913857677 @default.
• W4310506605 cites W2991653040 @default.
• W4310506605 cites W4233480692 @default.
• W4310506605 doi "https://doi.org/10.1007/s00294-022-01258-8" @default.
• W4310506605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36456733" @default.
• W4310506605 hasPublicationYear "2022" @default.
• W4310506605 type Work @default.
• W4310506605 citedByCount "0" @default.
• W4310506605 crossrefType "journal-article" @default.
• W4310506605 hasAuthorship W4310506605A5037610217 @default.
• W4310506605 hasAuthorship W4310506605A5039378102 @default.
• W4310506605 hasAuthorship W4310506605A5042170489 @default.
• W4310506605 hasAuthorship W4310506605A5045927822 @default.
• W4310506605 hasBestOaLocation W43105066052 @default.
• W4310506605 hasConcept C104317684 @default.
• W4310506605 hasConcept C138885662 @default.
• W4310506605 hasConcept C143065580 @default.
• W4310506605 hasConcept C153911025 @default.
• W4310506605 hasConcept C178790620 @default.
• W4310506605 hasConcept C179926584 @default.
• W4310506605 hasConcept C185592680 @default.
• W4310506605 hasConcept C190062978 @default.
• W4310506605 hasConcept C2775838275 @default.
• W4310506605 hasConcept C2776151105 @default.

• next