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• W4310506789 abstract "The unbinding pathway of a protein complex can vary significantly depending on biochemical and mechanical factors. Under mechanical stress, a complex may dissociate through a mechanism different from that used in simple thermal dissociation, leading to different dissociation rates under shear force and thermal dissociation. This is a well-known phenomenon studied in biomechanics whose molecular and atomic details are still elusive. A particularly interesting case is the complex formed by bacterial adhesins with their human peptide target. These protein interactions have a force resilience equivalent to those of covalent bonds, an order of magnitude stronger than the widely used streptavidin:biotin complex, while having an ordinary affinity, much lower than that of streptavidin:biotin. Here, in an in silico single-molecule force spectroscopy approach, we use molecular dynamics simulations to investigate the dissociation mechanism of adhesin/peptide complexes. We show how the Staphylococcus epidermidis adhesin SdrG uses a catch-bond mechanism to increase complex stability with increasing mechanical stress. While allowing for thermal dissociation in a low-force regime, an entirely different mechanical dissociation path emerges in a high-force regime, revealing an intricate mechanism that does not depend on the peptide's amino acid sequence. Using a dynamic network analysis approach, we identified key amino acid contacts that describe the mechanics of this complex, revealing differences in dynamics that hinder thermal dissociation and establish the mechanical dissociation path. We then validate the information content of the selected amino acid contacts using their dynamics to successfully predict the rupture forces for this complex through a machine learning model." @default.
• W4310506789 created "2022-12-11" @default.
• W4310506789 creator A5008576911 @default.
• W4310506789 creator A5020634590 @default.
• W4310506789 creator A5021152068 @default.
• W4310506789 date "2022-12-01" @default.
• W4310506789 modified "2023-09-23" @default.
• W4310506789 title "Molecular Origins of Force-Dependent Protein Complex Stabilization during Bacterial Infections" @default.
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• W4310506789 doi "https://doi.org/10.1021/jacs.2c07674" @default.
• W4310506789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36455202" @default.
• W4310506789 hasPublicationYear "2022" @default.
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