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- W4310519190 abstract "Heparin, a member of the glycosaminoglycan (GAG) family, is an extremely acidic sulfur-containing polysaccharide which has been suggested to be coupled with protein aggregation-related diseases including Alzheimer's, Parkinson's and Prion diseases. Here, we study the effect of heparin on the cetyltrimethylammonium bromide (CTAB)-induced aggregation of bovine serum albumin (BSA) exploiting biophysical approaches. Kinetic measurements indicated that heparin caused complete inhibition of CTAB-induced aggregation of protein with a significant decrease in the apparent rate constant. Far- and near-UV CD measurements depicted that CTAB behaves as a protein-aggregating agent. However, the perturbation of secondary and tertiary structure-induced by CTAB and the CTAB-induced amyloid formation of protein were prevented by heparin. ITC measurements revealed that enhancement of aggregation induced by CTAB was as a result of sequential binding in which CTAB binds with the protein and accompanied by exothermic heat of interaction. ITC measurements also showed that CTAB and heparin form complex while the complex does not bind with protein. Thus, we hypothesize that CTAB-Heparin complex is engaged in the inhibition of protein aggregation. Therefore, the mechanism of action of CTAB-heparin complex in inhibition of protein aggregation may be used as a basis of the development of therapeutic strategies of various neurodegenerative complications." @default.
- W4310519190 created "2022-12-11" @default.
- W4310519190 creator A5021703800 @default.
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- W4310519190 creator A5081455967 @default.
- W4310519190 date "2023-03-01" @default.
- W4310519190 modified "2023-10-08" @default.
- W4310519190 title "Counteraction of the cetyltrimethylammonium bromide-induced protein aggregation by heparin: Potential impact on protein aggregation and neurodegenerative diseases using biophysical approaches" @default.
- W4310519190 cites W1481393922 @default.
- W4310519190 cites W1533569014 @default.
- W4310519190 cites W1537908480 @default.
- W4310519190 cites W1540384848 @default.
- W4310519190 cites W1593567129 @default.
- W4310519190 cites W1827205038 @default.
- W4310519190 cites W1833346013 @default.
- W4310519190 cites W1965420960 @default.
- W4310519190 cites W1966721430 @default.
- W4310519190 cites W1976949015 @default.
- W4310519190 cites W1978617962 @default.
- W4310519190 cites W1984780758 @default.
- W4310519190 cites W1987093238 @default.
- W4310519190 cites W2004176946 @default.
- W4310519190 cites W2006257709 @default.
- W4310519190 cites W2007975050 @default.
- W4310519190 cites W2014161432 @default.
- W4310519190 cites W2014485936 @default.
- W4310519190 cites W2018459739 @default.
- W4310519190 cites W2019041725 @default.
- W4310519190 cites W2020509283 @default.
- W4310519190 cites W2021914048 @default.
- W4310519190 cites W2024477884 @default.
- W4310519190 cites W2025193843 @default.
- W4310519190 cites W2029053759 @default.
- W4310519190 cites W2029349765 @default.
- W4310519190 cites W2033868382 @default.
- W4310519190 cites W2035232504 @default.
- W4310519190 cites W2039335048 @default.
- W4310519190 cites W2044623253 @default.
- W4310519190 cites W2046380939 @default.
- W4310519190 cites W2051711382 @default.
- W4310519190 cites W2055661401 @default.
- W4310519190 cites W2059357684 @default.
- W4310519190 cites W2063113735 @default.
- W4310519190 cites W2068279659 @default.
- W4310519190 cites W2070380111 @default.
- W4310519190 cites W2077897611 @default.
- W4310519190 cites W2079257101 @default.
- W4310519190 cites W2080442263 @default.
- W4310519190 cites W2083954559 @default.
- W4310519190 cites W2084227558 @default.
- W4310519190 cites W2088364401 @default.
- W4310519190 cites W2091904816 @default.
- W4310519190 cites W2092361531 @default.
- W4310519190 cites W2095425304 @default.
- W4310519190 cites W2102869608 @default.
- W4310519190 cites W2116190871 @default.
- W4310519190 cites W2118360717 @default.
- W4310519190 cites W2134963281 @default.
- W4310519190 cites W2136637496 @default.
- W4310519190 cites W2145258357 @default.
- W4310519190 cites W2149588263 @default.
- W4310519190 cites W2151919617 @default.
- W4310519190 cites W2165186407 @default.
- W4310519190 cites W2168945601 @default.
- W4310519190 cites W2180818525 @default.
- W4310519190 cites W2318033572 @default.
- W4310519190 cites W2354149992 @default.
- W4310519190 cites W2461652024 @default.
- W4310519190 cites W2530718144 @default.
- W4310519190 cites W2588943247 @default.
- W4310519190 cites W2594424792 @default.
- W4310519190 cites W2598328231 @default.
- W4310519190 cites W2606007784 @default.
- W4310519190 cites W2614053601 @default.
- W4310519190 cites W2616510207 @default.
- W4310519190 cites W2621293069 @default.
- W4310519190 cites W2738451310 @default.
- W4310519190 cites W2739584186 @default.
- W4310519190 cites W2906357519 @default.
- W4310519190 cites W3046049047 @default.
- W4310519190 cites W3123942552 @default.
- W4310519190 cites W3133605594 @default.
- W4310519190 cites W3136668638 @default.
- W4310519190 cites W3201353420 @default.
- W4310519190 cites W4200518337 @default.
- W4310519190 cites W4284974005 @default.
- W4310519190 cites W4308722882 @default.
- W4310519190 doi "https://doi.org/10.1016/j.molstruc.2022.134714" @default.
- W4310519190 hasPublicationYear "2023" @default.
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