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- W4310525098 endingPage "1105" @default.
- W4310525098 startingPage "1105" @default.
- W4310525098 abstract "The quantitative detection of critical biomolecules and in particular low-abundance biomarkers in biofluids is crucial for early-stage diagnosis and management but remains a challenge largely owing to the insufficient sensitivity of existing ensemble-sensing methods. The single-particle imaging technique has emerged as an important tool to analyze ultralow-abundance biomolecules by engineering and exploiting the distinct physical and chemical property of individual luminescent particles. In this review, we focus and survey the latest advances in single-particle optical imaging (OSPI) for ultrasensitive bioanalysis pertaining to basic biological studies and clinical applications. We first introduce state-of-the-art OSPI techniques, including fluorescence, surface-enhanced Raman scattering, electrochemiluminescence, and dark-field scattering, with emphasis on the contributions of various metal and nonmetal nano-labels to the improvement of the signal-to-noise ratio. During the discussion of individual techniques, we also highlight their applications in spatial–temporal measurement of key biomarkers such as proteins, nucleic acids and extracellular vesicles with single-entity sensitivity. To that end, we discuss the current challenges and prospective trends of single-particle optical-imaging-based bioanalysis." @default.
- W4310525098 created "2022-12-11" @default.
- W4310525098 creator A5016038041 @default.
- W4310525098 creator A5053881889 @default.
- W4310525098 creator A5060480074 @default.
- W4310525098 creator A5086060866 @default.
- W4310525098 date "2022-12-01" @default.
- W4310525098 modified "2023-10-14" @default.
- W4310525098 title "Single-Particle Optical Imaging for Ultrasensitive Bioanalysis" @default.
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