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• W4310542953 abstract "Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated.MPV and plateletcrit levels of both CLL and control group were compared and then in CLL patients, additional diseases, leukocyte count, platelet count, lactate dehydrogenase, Rai stage, progression-free and overall survival, mutations, if any, and chemotherapy, if any, were recorded. Then, the relationship between MPV and plateletcrit values and these parameters were evaluated in CLL patients.Platelet and plateletcrit values were found to be significantly lower in CLL patients than the control group (p<0.001) for both. Plateletcrit and MPV values of patients who did not receive chemotherapy were higher than those who received chemotherapy (p=0.03, p=0.02, respectively). Being over 75 years old, plateletcrit value less than 0.1565 %, platelet level below 175 x 109/L, and leukocyte count greater than 53.5 x 109/L was found to significantly reduce overall survival. Male gender, each stage increase, plateletcrit less than 0.1565 % and leukocyte count greater than 53.5 x 109/L was related to reduce treatment-free survival in CLL patients.Plateletcrit can be a viable prognostic marker for defining both treatment free and overall survival.Promene trombocita i srednjeg volumena trombocita (MPV) i patogeneze hronične limfocitne leukemije (CLL) su povezane sa različitim inflamatornim poremećajima. Procenjen je prognostički uticaj trombocita i MPV.Nivoi MPV-a i trombocita u HLL i kontrolnoj grupi su upoređeni, a zatim kod pacijenata sa CLL, dodatne bolesti, broj leukocita, broj trombocita, laktat dehidrogenaza, Rai stadijum, opstanak bez progresije i ukupno preživljavanje, mutacije, ako ih ima, i hemoterapija, ako ih ima, snimljeni su. Zatim je procenjen odnos između vrednosti MPV i trombocita i ovih parametara kod pacijenata sa CLL.Utvrđeno je da su vrednosti trombocita i trombocita značajno niže kod pacijenata sa CLL u odnosu na kontrolnu grupu (p<0,001) za oba. Vrednosti trombocita i MPV kod pacijenata koji nisu primali hemoterapiju su bile veće od onih koji su primali hemoterapiju (p=0,03, p=0,02, respektivno). Kod starijih od 75 godina, vrednost trombocita manja od 0,1565%, nivo trombocita ispod 175 x 109/L i broj leukocita veći od 53,5 x 109/L su značajno smanjili ukupno preživljavanje. Muški pol, povećanje u svakom stepenu, trombocitni krit manji od 0,1565 % i broj leukocita veći od 53,5 x 109/L bili su povezani sa smanjenjem preživljavanja bez terapije kod pacijenata sa CLL.Trombocitni broj može biti održiv prognostički marker za definisanje preživljavanja bez lečenja i ukupnog preživljavanja." @default.
• W4310542953 created "2022-12-11" @default.
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• W4310542953 date "2023-01-01" @default.
• W4310542953 modified "2023-10-01" @default.
• W4310542953 title "Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia" @default.
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• W4310542953 doi "https://doi.org/10.5937/jomb0-39375" @default.
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