FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310542955> ?p ?o ?g. }

• W4310542955 endingPage "102563" @default.
• W4310542955 startingPage "102563" @default.
• W4310542955 abstract "The imbalance of redox homeostasis induces hyper-inflammation in viral infections. In this study, we explored the redox system signature in response to SARS-COV-2 infection and examined the status of these extracellular and intracellular signatures in COVID-19 patients.The multi-level network was constructed using multi-level data of oxidative stress-related biological processes, protein-protein interactions, transcription factors, and co-expression coefficients obtained from GSE164805, which included gene expression profiles of peripheral blood mononuclear cells (PBMCs) from COVID-19 patients and healthy controls. Top genes were designated based on the degree and closeness centralities. The expression of high-ranked genes was evaluated in PBMCs and nasopharyngeal (NP) samples of 30 COVID-19 patients and 30 healthy controls. The intracellular levels of GSH and ROS/O2• - and extracellular oxidative stress markers were assayed in PBMCs and plasma samples by flow cytometry and ELISA. ELISA results were applied to construct a classification model using logistic regression to differentiate COVID-19 patients from healthy controls.CAT, NFE2L2, SOD1, SOD2 and CYBB were 5 top genes in the network analysis. The expression of these genes and intracellular levels of ROS/O2• - were increased in PBMCs of COVID-19 patients while the GSH level decreased. The expression of high-ranked genes was lower in NP samples of COVID-19 patients compared to control group. The activity of extracellular enzymes CAT and SOD, and the total oxidant status (TOS) level were increased in plasma samples of COVID-19 patients. Also, the 2-marker panel of CAT and TOS and 3-marker panel showed the best performance.SARS-COV-2 disrupts the redox equilibrium in immune cells and the upper respiratory tract, leading to exacerbated inflammation and increased replication and entrance of SARS-COV-2 into host cells. Furthermore, utilizing markers of oxidative stress as a complementary validation to discriminate COVID-19 from healthy controls, seems promising." @default.
• W4310542955 created "2022-12-11" @default.
• W4310542955 creator A5003046014 @default.
• W4310542955 creator A5004425214 @default.
• W4310542955 creator A5006060805 @default.
• W4310542955 creator A5007043417 @default.
• W4310542955 creator A5018739716 @default.
• W4310542955 creator A5024152223 @default.
• W4310542955 creator A5052434590 @default.
• W4310542955 creator A5056953085 @default.
• W4310542955 creator A5068840754 @default.
• W4310542955 creator A5072254700 @default.
• W4310542955 creator A5085920379 @default.
• W4310542955 date "2023-02-01" @default.
• W4310542955 modified "2023-10-01" @default.
• W4310542955 title "New insights into extracellular and intracellular redox status in COVID-19 patients" @default.
• W4310542955 cites W1976599392 @default.
• W4310542955 cites W2003305424 @default.
• W4310542955 cites W2011551551 @default.
• W4310542955 cites W2054129051 @default.
• W4310542955 cites W2074873714 @default.
• W4310542955 cites W2084141237 @default.
• W4310542955 cites W2105081948 @default.
• W4310542955 cites W2127157208 @default.
• W4310542955 cites W2507225417 @default.
• W4310542955 cites W2566510183 @default.
• W4310542955 cites W2583179451 @default.
• W4310542955 cites W2793517230 @default.
• W4310542955 cites W2802829367 @default.
• W4310542955 cites W2804408552 @default.
• W4310542955 cites W2900569176 @default.
• W4310542955 cites W2909364225 @default.
• W4310542955 cites W3001118548 @default.
• W4310542955 cites W3003192283 @default.
• W4310542955 cites W3008452791 @default.
• W4310542955 cites W3013893137 @default.
• W4310542955 cites W3020993161 @default.
• W4310542955 cites W3023991776 @default.
• W4310542955 cites W3031739230 @default.
• W4310542955 cites W3038053879 @default.
• W4310542955 cites W3042922222 @default.
• W4310542955 cites W3044086428 @default.
• W4310542955 cites W3044614759 @default.
• W4310542955 cites W3046194290 @default.
• W4310542955 cites W3092152431 @default.
• W4310542955 cites W3092339733 @default.
• W4310542955 cites W3094165762 @default.
• W4310542955 cites W3108406790 @default.
• W4310542955 cites W3112062274 @default.
• W4310542955 cites W3112917974 @default.
• W4310542955 cites W3119506213 @default.
• W4310542955 cites W3130105134 @default.
• W4310542955 cites W3130206057 @default.
• W4310542955 cites W3153804665 @default.
• W4310542955 cites W3165418999 @default.
• W4310542955 cites W3168224223 @default.
• W4310542955 cites W3170912470 @default.
• W4310542955 cites W3179966256 @default.
• W4310542955 cites W3193480463 @default.
• W4310542955 cites W3194189342 @default.
• W4310542955 cites W4205673893 @default.
• W4310542955 cites W4211245864 @default.
• W4310542955 cites W4226075435 @default.
• W4310542955 cites W4226146755 @default.
• W4310542955 cites W4244577475 @default.
• W4310542955 cites W4289544781 @default.
• W4310542955 doi "https://doi.org/10.1016/j.redox.2022.102563" @default.
• W4310542955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36493512" @default.
• W4310542955 hasPublicationYear "2023" @default.
• W4310542955 type Work @default.
• W4310542955 citedByCount "5" @default.
• W4310542955 countsByYear W43105429552023 @default.
• W4310542955 crossrefType "journal-article" @default.
• W4310542955 hasAuthorship W4310542955A5003046014 @default.
• W4310542955 hasAuthorship W4310542955A5004425214 @default.
• W4310542955 hasAuthorship W4310542955A5006060805 @default.
• W4310542955 hasAuthorship W4310542955A5007043417 @default.
• W4310542955 hasAuthorship W4310542955A5018739716 @default.
• W4310542955 hasAuthorship W4310542955A5024152223 @default.
• W4310542955 hasAuthorship W4310542955A5052434590 @default.
• W4310542955 hasAuthorship W4310542955A5056953085 @default.
• W4310542955 hasAuthorship W4310542955A5068840754 @default.
• W4310542955 hasAuthorship W4310542955A5072254700 @default.
• W4310542955 hasAuthorship W4310542955A5085920379 @default.
• W4310542955 hasBestOaLocation W43105429551 @default.
• W4310542955 hasConcept C104317684 @default.
• W4310542955 hasConcept C134018914 @default.
• W4310542955 hasConcept C137061746 @default.
• W4310542955 hasConcept C150194340 @default.
• W4310542955 hasConcept C202751555 @default.
• W4310542955 hasConcept C203014093 @default.
• W4310542955 hasConcept C2775838275 @default.
• W4310542955 hasConcept C2776108821 @default.
• W4310542955 hasConcept C2776151105 @default.
• W4310542955 hasConcept C28406088 @default.
• W4310542955 hasConcept C48349386 @default.
• W4310542955 hasConcept C553184892 @default.
• W4310542955 hasConcept C55493867 @default.

• next