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• W4310551750 abstract "Convergent evolution is central to the study of adaptation and has been used to understand both the limits of evolution and the diverse patterns and processes which result in adaptive change. Resistance to snake venom alpha-neurotoxins ( α NTXs) is a case of widespread convergence having evolved several times in snakes, lizards and mammals. Despite extreme toxicity of α NTXs, substitutions in its target, the nicotinic acetylcholine receptor (nAChR), prevent α NTX binding and render species resistant. Recently, the published meerkat (Herpestidae) genome revealed that meerkats have the same substitutions in nAChR as the venom-resistant Egyptian mongoose (Herpestidae), suggesting that venom-resistant nAChRs may be ancestral to Herpestids. Like the mongoose, many other species of feliform carnivores prey on venomous snakes, though their venom resistance has never been explored. To evaluate the prevalence and ancestry of α NTX resistance in mammals, we generate a dataset of mammalian nAChR using museum specimens and public datasets. We find five instances of convergent evolution within feliform carnivores, and an additional eight instances across all mammals sampled. Tests of selection show that these substitutions are evolving under positive selection. Repeated convergence suggests that this adaptation played an important role in the evolution of mammalian physiology and potentially venom evolution." @default.
• W4310551750 created "2022-12-12" @default.
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• W4310551750 date "2022-11-01" @default.
• W4310551750 modified "2023-09-26" @default.
• W4310551750 title "Widespread convergent evolution of alpha-neurotoxin resistance in African mammals" @default.
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• W4310551750 doi "https://doi.org/10.1098/rsbl.2022.0361" @default.
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