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- W4310553732 abstract "Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer factor) family of transcription factors, inhibits vascular smooth muscle cell differentiation. This study hints at potential interventions to maintain a normal, differentiated smooth muscle cell state, thereby eliminating the pathogenesis of AAA. In addition, our study provides insights into the potential use of TCF7L1 as a biomarker for AAA." @default.
- W4310553732 created "2022-12-12" @default.
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- W4310553732 date "2023-02-01" @default.
- W4310553732 modified "2023-10-18" @default.
- W4310553732 title "TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms" @default.
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- W4310553732 doi "https://doi.org/10.1016/j.jacbts.2022.07.012" @default.
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