Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310555473> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4310555473 endingPage "32" @default.
- W4310555473 startingPage "28" @default.
- W4310555473 abstract "Metformin hydrochloride (MET) is an oral hypoglycemic agent which improves glucose tolerance in patients with type 2 diabetes and diminishes basal plasma levels of glucose. The aim of this study was to develop and optimize MET matrix tablets for SR application. The SR matrix tablet of MET was prepared by wet granulation technique using Polyvinyl pyrrolidone K30 and hydroxyl propyl methylcellulose of different viscosity grades (HPMC K4M, HPMC K15M, and HPMC K100M). The influence of varying the polymer ratios was evaluated. The excipients used in this study did not modify physicochemical properties of the drug. MET has relatively short plasma half-life, low absolute bioavailability. The need for the administration 2 to 3 times a day when larger doses are required can decrease patient fulfillment. SR formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of MET. SR products are needed for MET to prolong its duration of action and to improve patient compliances. The development of oral sustained release systems has been a challenge to formulation scientists due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. From all the formulation trial batches, formulation F3 shows the best results. It has been observed that HPMC K100M alone cannot give satisfactory drug release profile but the blend of HPMC K100M and Polyvinyl pyrrolidone K30 together give the best drug release kinetics. Thus, sustained release matrix tablets of metformin hydrochloride can be expected to reduce the frequency of administration and decrease the dose dependent side effects. Keywords: Metformin hydrochloride, SR matrix tablet, HPMC K100M, Wet granulation technique" @default.
- W4310555473 created "2022-12-12" @default.
- W4310555473 creator A5024175804 @default.
- W4310555473 creator A5048506309 @default.
- W4310555473 creator A5062144661 @default.
- W4310555473 creator A5085659923 @default.
- W4310555473 date "2022-11-22" @default.
- W4310555473 modified "2023-10-14" @default.
- W4310555473 title "Formulation and Evaluation of Metformin Hydrochloride Sustained Release Tablet" @default.
- W4310555473 doi "https://doi.org/10.22270/ijmspr.v8i3.56" @default.
- W4310555473 hasPublicationYear "2022" @default.
- W4310555473 type Work @default.
- W4310555473 citedByCount "0" @default.
- W4310555473 crossrefType "journal-article" @default.
- W4310555473 hasAuthorship W4310555473A5024175804 @default.
- W4310555473 hasAuthorship W4310555473A5048506309 @default.
- W4310555473 hasAuthorship W4310555473A5062144661 @default.
- W4310555473 hasAuthorship W4310555473A5085659923 @default.
- W4310555473 hasBestOaLocation W43105554731 @default.
- W4310555473 hasConcept C106487976 @default.
- W4310555473 hasConcept C134018914 @default.
- W4310555473 hasConcept C159985019 @default.
- W4310555473 hasConcept C181389837 @default.
- W4310555473 hasConcept C185592680 @default.
- W4310555473 hasConcept C192562407 @default.
- W4310555473 hasConcept C2780035454 @default.
- W4310555473 hasConcept C2780323712 @default.
- W4310555473 hasConcept C2909500757 @default.
- W4310555473 hasConcept C3019981671 @default.
- W4310555473 hasConcept C43617362 @default.
- W4310555473 hasConcept C555293320 @default.
- W4310555473 hasConcept C71924100 @default.
- W4310555473 hasConcept C88463166 @default.
- W4310555473 hasConcept C98274493 @default.
- W4310555473 hasConceptScore W4310555473C106487976 @default.
- W4310555473 hasConceptScore W4310555473C134018914 @default.
- W4310555473 hasConceptScore W4310555473C159985019 @default.
- W4310555473 hasConceptScore W4310555473C181389837 @default.
- W4310555473 hasConceptScore W4310555473C185592680 @default.
- W4310555473 hasConceptScore W4310555473C192562407 @default.
- W4310555473 hasConceptScore W4310555473C2780035454 @default.
- W4310555473 hasConceptScore W4310555473C2780323712 @default.
- W4310555473 hasConceptScore W4310555473C2909500757 @default.
- W4310555473 hasConceptScore W4310555473C3019981671 @default.
- W4310555473 hasConceptScore W4310555473C43617362 @default.
- W4310555473 hasConceptScore W4310555473C555293320 @default.
- W4310555473 hasConceptScore W4310555473C71924100 @default.
- W4310555473 hasConceptScore W4310555473C88463166 @default.
- W4310555473 hasConceptScore W4310555473C98274493 @default.
- W4310555473 hasIssue "3" @default.
- W4310555473 hasLocation W43105554731 @default.
- W4310555473 hasOpenAccess W4310555473 @default.
- W4310555473 hasPrimaryLocation W43105554731 @default.
- W4310555473 hasRelatedWork W118449968 @default.
- W4310555473 hasRelatedWork W1508531867 @default.
- W4310555473 hasRelatedWork W2030193124 @default.
- W4310555473 hasRelatedWork W2744667494 @default.
- W4310555473 hasRelatedWork W2770007752 @default.
- W4310555473 hasRelatedWork W2782734952 @default.
- W4310555473 hasRelatedWork W3024440267 @default.
- W4310555473 hasRelatedWork W4307128310 @default.
- W4310555473 hasRelatedWork W2181418653 @default.
- W4310555473 hasRelatedWork W2184264123 @default.
- W4310555473 hasVolume "8" @default.
- W4310555473 isParatext "false" @default.
- W4310555473 isRetracted "false" @default.
- W4310555473 workType "article" @default.