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• W4310558170 abstract "Zebrafish are being widely used to study central nervous system diseases such as epilepsy. Over the last two decades, research on zebrafish models contributed to our understanding of brain development as well as pathological processes involved in disease. Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutations in TSC1 or TSC2 genes. TSC patients suffer from seizures associated with dysregulated mTOR signaling. Here, we focused on specific methodologies used to study epilepsy-like phenotype in the TSC fish highlighting the value of zebrafish as a model to study epilepsy. The availability of powerful and effective techniques like brain activity imaging, behavioral tracking, and high-resolution microscopy in developing animals makes zebrafish useful to study epilepsy pathogenesis on different levels. Moreover, external development, quick maturation, and ease of genetic manipulation are also advantageous. Furthermore, we also summarize other genetic or chemically induced epilepsy models made in zebrafish. Comprehensive knowledge in this chapter may help researchers to design their own studies using zebrafish as an animal model." @default.
• W4310558170 created "2022-12-12" @default.
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• W4310558170 date "2023-01-01" @default.
• W4310558170 modified "2023-09-26" @default.
• W4310558170 title "The zebrafish model of Tuberous sclerosis complex to study epilepsy" @default.
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• W4310558170 doi "https://doi.org/10.1016/b978-0-323-89833-1.00031-8" @default.
• W4310558170 hasPublicationYear "2023" @default.
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