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• W4310558188 abstract "Bisphenol A (BPA) is an endocrine disruptor compound extensively used in the production of epoxy resins and polycarbonate plastics. BPA disrupts mitochondrial functions through many molecular mechanisms. Mitochondria are the center of cellular energy and therefore are the target of many endocrine-disrupting chemicals. The association between oxidative stress and mitochondrial dysfunction induced by BPA and various human diseases has been identified. BPA impairs redox homeostasis via increasing ROS levels essentially in mitochondrial complex I; decreasing antioxidant enzymes; decreasing the activities of mitochondrial complexes I, II, III, IV, and V; decreasing the mitochondrial membrane potential; and reducing ATP production and ultimately causing mitochondrial dysfunction and apoptosis. BPA decreases the expression of genes involved in mitochondrial biogenesis and mitochondria content. Also, by increasing the expression and accumulation of genes linked to mitophagy in the damaged mitochondria, BPA removes unhealthy mitochondria and decreases mitochondrial mass." @default.
• W4310558188 created "2022-12-12" @default.
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• W4310558188 date "2023-01-01" @default.
• W4310558188 modified "2023-09-26" @default.
• W4310558188 title "Mechanisms of bisphenol A toxicity in mitochondria" @default.
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• W4310558188 doi "https://doi.org/10.1016/b978-0-323-88462-4.00020-1" @default.
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