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- W4310558240 endingPage "661" @default.
- W4310558240 startingPage "615" @default.
- W4310558240 abstract "Polychlorinated biphenyls (PCBs) are a family of 209 anthropogenic compounds that are highly hydrophobic and persist in the environment. They have been associated with various toxic effects in organisms. At the cellular level, PCB exposure was linked to an increase in oxidative stress. Mitochondria are one of the main sources of intracellular reactive oxygen species and, thus, a major target for PCB toxicity. In the last 50 years, our understanding of toxic effects of PCBs toward the mitochondria improved. Overall, studies showed that interactions of PCB congeners with mitochondrial function depend on structural features. Especially, non-planar PCBs, i.e., ortho-substituted congeners, appear more potent for inducing toxicity to the mitochondrion. A variety of effects has been reported following exposure to PCBs; they can alter the structure of mitochondria, including membrane integrity, inhibit proper function of the respiratory chain, affect calcium storage, and dysregulate apoptosis mechanisms in vivo and in vitro. While specific interactions with cellular targets were identified along the respiratory chain, the majority of the research strongly indicates that loss of mitochondrial function is subsequent to a non-specific increase in ion permeability following integration of PCBs within the lipid bilayer and disruption of membrane integrity. Altogether, toxic effects of PCBs on mitochondria appear central to oxidative stress generation and to the development of associated negative health outcomes described in the literature, such as neurotoxicity, reprotoxicity, metabolic alterations, and cancer." @default.
- W4310558240 created "2022-12-12" @default.
- W4310558240 creator A5068827052 @default.
- W4310558240 date "2023-01-01" @default.
- W4310558240 modified "2023-09-30" @default.
- W4310558240 title "Polychlorinated biphenyls" @default.
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