Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310558293> ?p ?o ?g. }
- W4310558293 endingPage "C84" @default.
- W4310558293 startingPage "C76" @default.
- W4310558293 abstract "As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are involved in multiple pathophysiological processes at the apex of cell signaling cascades, and as endocytosis receptors for particle structures, such as lipoproteins, extracellular vesicles, and enveloped viruses, including SARS-CoV-2. Given their diversity and complex biogenesis regulation, HSPGs remain understudied. Here we compile some of the latest studies focusing on HSPGs as internalizing receptors of extracellular vesicles (“endogenous virus”) and SARS-CoV-2 lipid-enclosed particles and highlight similarities in their biophysical and structural characteristics. Specifically, the similarities in their biogenesis, size, and lipid composition may explain a common dependence on HSPGs for efficient cell-surface attachment and uptake. We further discuss the relative complexity of extracellular vesicle composition and the viral mechanisms that evolve towards increased infectivity that complicate therapeutic strategies addressing blockade of their uptake." @default.
- W4310558293 created "2022-12-12" @default.
- W4310558293 creator A5009891370 @default.
- W4310558293 creator A5076890243 @default.
- W4310558293 creator A5089718315 @default.
- W4310558293 date "2023-01-01" @default.
- W4310558293 modified "2023-09-30" @default.
- W4310558293 title "Proteoglycans: a common portal for SARS-CoV-2 and extracellular vesicle uptake" @default.
- W4310558293 cites W1503710420 @default.
- W4310558293 cites W1539308578 @default.
- W4310558293 cites W1545930970 @default.
- W4310558293 cites W1558905924 @default.
- W4310558293 cites W1609951617 @default.
- W4310558293 cites W176235732 @default.
- W4310558293 cites W1898194260 @default.
- W4310558293 cites W1950118853 @default.
- W4310558293 cites W1955765029 @default.
- W4310558293 cites W1960512949 @default.
- W4310558293 cites W1970733468 @default.
- W4310558293 cites W1971351550 @default.
- W4310558293 cites W1976210935 @default.
- W4310558293 cites W1980226233 @default.
- W4310558293 cites W1999469165 @default.
- W4310558293 cites W2000153205 @default.
- W4310558293 cites W2006641366 @default.
- W4310558293 cites W2008349434 @default.
- W4310558293 cites W2008627178 @default.
- W4310558293 cites W2012482503 @default.
- W4310558293 cites W2031325281 @default.
- W4310558293 cites W2038236600 @default.
- W4310558293 cites W2041703901 @default.
- W4310558293 cites W2045905998 @default.
- W4310558293 cites W2054077259 @default.
- W4310558293 cites W2058229406 @default.
- W4310558293 cites W2058940197 @default.
- W4310558293 cites W2066432115 @default.
- W4310558293 cites W2091023302 @default.
- W4310558293 cites W2095407038 @default.
- W4310558293 cites W2098364791 @default.
- W4310558293 cites W2130363568 @default.
- W4310558293 cites W2130523142 @default.
- W4310558293 cites W2131466739 @default.
- W4310558293 cites W2142226955 @default.
- W4310558293 cites W2152821878 @default.
- W4310558293 cites W2154314925 @default.
- W4310558293 cites W2160578982 @default.
- W4310558293 cites W2169275487 @default.
- W4310558293 cites W2173706466 @default.
- W4310558293 cites W2210048592 @default.
- W4310558293 cites W2251801487 @default.
- W4310558293 cites W2272616382 @default.
- W4310558293 cites W2274058631 @default.
- W4310558293 cites W2298105916 @default.
- W4310558293 cites W2406009985 @default.
- W4310558293 cites W2527876252 @default.
- W4310558293 cites W2579651244 @default.
- W4310558293 cites W2604437060 @default.
- W4310558293 cites W2728126685 @default.
- W4310558293 cites W2751967288 @default.
- W4310558293 cites W2763644153 @default.
- W4310558293 cites W2768279801 @default.
- W4310558293 cites W2791013480 @default.
- W4310558293 cites W2791929441 @default.
- W4310558293 cites W2792418106 @default.
- W4310558293 cites W2801709935 @default.
- W4310558293 cites W2806400505 @default.
- W4310558293 cites W2895043275 @default.
- W4310558293 cites W2904802348 @default.
- W4310558293 cites W2911953492 @default.
- W4310558293 cites W2913463049 @default.
- W4310558293 cites W2913503958 @default.
- W4310558293 cites W2946533222 @default.
- W4310558293 cites W2950778827 @default.
- W4310558293 cites W2955657632 @default.
- W4310558293 cites W2967618252 @default.
- W4310558293 cites W2991241472 @default.
- W4310558293 cites W3002486005 @default.
- W4310558293 cites W3009912996 @default.
- W4310558293 cites W3024900029 @default.
- W4310558293 cites W3041474915 @default.
- W4310558293 cites W3043594036 @default.
- W4310558293 cites W3043649968 @default.
- W4310558293 cites W3044069820 @default.
- W4310558293 cites W3085153423 @default.
- W4310558293 cites W3094318117 @default.
- W4310558293 cites W3111774961 @default.
- W4310558293 cites W3113857306 @default.
- W4310558293 cites W3118607940 @default.
- W4310558293 cites W3127860141 @default.
- W4310558293 cites W3137162930 @default.
- W4310558293 cites W3138695941 @default.
- W4310558293 cites W3175341024 @default.
- W4310558293 cites W3195878610 @default.
- W4310558293 cites W3199388289 @default.
- W4310558293 cites W3203433659 @default.
- W4310558293 cites W4214566503 @default.
- W4310558293 cites W4220657135 @default.
- W4310558293 cites W4286638683 @default.