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- W4310559211 abstract "Various animal models of Alzheimer’s disease (AD) have been developed to investigate the disease pathophysiology and novel therapeutic approaches. However, most AD models described up to date can closely reproduce the familial (genetic) aspects of the disease; yet, the most prevailing type of AD is the sporadic (late onset) type. The lack of appropriate animal models that can reproduce the pathological features of sporadic AD and the disease risk factors may explain the failure of many animal studies to be translated to clinical settings. Disturbance of brain insulin signaling during aging is believed to be a main contributing factor to the late onset AD. In this chapter, we will describe a new approach to model sporadic AD by intracerebroventricular injection of Streptozotocin (STZ), a diabetogenic agent, into APP/PS1 AD mouse brain. We will provide evidence that STZ-APP/PS1 mouse model can recapitulate the main neuropathological features of AD such as neuroinflammation, neuronal apoptosis, oxidative stress, and accumulation of amyloid plaques and hyperphosphorylated Tau protein in a progressive manner that correlates with synaptic and cognitive changes observed in sporadic AD. Based on these findings, we propose that STZ-APP/PS1 model can be used as a model of sporadic AD to reproduce both genetic and environmental aspects of the disease, making this model suitable for future research into AD pathophysiology and testing novel therapeutics." @default.
- W4310559211 created "2022-12-12" @default.
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- W4310559211 date "2023-01-01" @default.
- W4310559211 modified "2023-09-26" @default.
- W4310559211 title "Sporadic Alzheimer’s disease animal model using streptozotocin and APP/PS1 mice" @default.
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- W4310559211 doi "https://doi.org/10.1016/b978-0-323-89833-1.00026-4" @default.
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