FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310563722> ?p ?o ?g. }

• W4310563722 endingPage "54606" @default.
• W4310563722 startingPage "54598" @default.
• W4310563722 abstract "Biocatalytic transformations in living cells, such as enzymatic cascades, function effectively in spatially confined microenvironments. However, mimicking enzyme catalytic cascade processes is challenging. Herein, we report a new dual-Hemin-G-quadruplex (dHemin-G4) DNAzyme with high catalytic activity over noncovalent G4/Hemin and monocovalent counterparts (G4-Hemin and Hemin-G4) by covalently linking hemin to both ends of an intramolecular G4. We use MAF-7, a hydrophilic metal-organic framework (MOF), as the protecting scaffold to integrate a biocatalytic cascade consisting of dHemin-G4 DNAzyme and glucose oxidase (GOx), by a simple and mild method with a single-step encapsulation of both enzymes. Such a MAF-7-confined cascade system shows superior activity over not only traditional G4/Hemin but also other MOFs (ZIF-8 and ZIF-90), which was mainly attributed to high-payload enzyme packaging. Notably, the introduction of hydrophilic G4 allows to avoid the accumulation of hydrophobic hemin on the surface of MAF-7, which decreases cascade biocatalytic activity. Furthermore, MAF-7 as protective coatings endowed the enzyme with excellent recyclability and good operational stability in harsh environments, including elevated temperature, urea, protease, and organic solvents, extending its practical application in biocatalysis. In addition, the incorporated enzymes can be replaced on demand to broaden the scope of catalytic substrates. Taking advantages of these features, the feasibility of dHemin-G4/GOx@MAF-7 systems for biosensing was demonstrated. This study is conducive to devise efficient and stable enzyme catalytic cascades to facilitate applications in biosensing and industrial processes." @default.
• W4310563722 created "2022-12-12" @default.
• W4310563722 creator A5000221751 @default.
• W4310563722 creator A5002809217 @default.
• W4310563722 creator A5009102045 @default.
• W4310563722 creator A5017375525 @default.
• W4310563722 creator A5020321309 @default.
• W4310563722 creator A5022523046 @default.
• W4310563722 creator A5091118881 @default.
• W4310563722 creator A5091388649 @default.
• W4310563722 date "2022-12-02" @default.
• W4310563722 modified "2023-10-18" @default.
• W4310563722 title "A Double Hemin Bonded G-Quadruplex Embedded in Metal–Organic Frameworks for Biomimetic Cascade Reaction" @default.
• W4310563722 cites W1900889511 @default.
• W4310563722 cites W1992562921 @default.
• W4310563722 cites W1993341333 @default.
• W4310563722 cites W2003213689 @default.
• W4310563722 cites W2015503736 @default.
• W4310563722 cites W2017980560 @default.
• W4310563722 cites W2023978004 @default.
• W4310563722 cites W2068468372 @default.
• W4310563722 cites W2096699174 @default.
• W4310563722 cites W2102424174 @default.
• W4310563722 cites W2162103152 @default.
• W4310563722 cites W2163480486 @default.
• W4310563722 cites W2167358549 @default.
• W4310563722 cites W2315138333 @default.
• W4310563722 cites W2325185050 @default.
• W4310563722 cites W2346463032 @default.
• W4310563722 cites W2483439092 @default.
• W4310563722 cites W2512953958 @default.
• W4310563722 cites W2549401396 @default.
• W4310563722 cites W2560697259 @default.
• W4310563722 cites W2562620884 @default.
• W4310563722 cites W2580658395 @default.
• W4310563722 cites W2600637604 @default.
• W4310563722 cites W2611605800 @default.
• W4310563722 cites W2614047159 @default.
• W4310563722 cites W2763562657 @default.
• W4310563722 cites W2766503879 @default.
• W4310563722 cites W2783341541 @default.
• W4310563722 cites W2794506230 @default.
• W4310563722 cites W2805016605 @default.
• W4310563722 cites W2810797266 @default.
• W4310563722 cites W2886864981 @default.
• W4310563722 cites W2907011108 @default.
• W4310563722 cites W2908532599 @default.
• W4310563722 cites W2982318689 @default.
• W4310563722 cites W2985588002 @default.
• W4310563722 cites W2990213613 @default.
• W4310563722 cites W2998047964 @default.
• W4310563722 cites W3010732601 @default.
• W4310563722 cites W3044986280 @default.
• W4310563722 cites W3099191958 @default.
• W4310563722 cites W3119786711 @default.
• W4310563722 cites W3193016336 @default.
• W4310563722 cites W3196876899 @default.
• W4310563722 cites W4206568636 @default.
• W4310563722 cites W4206987873 @default.
• W4310563722 cites W4210970969 @default.
• W4310563722 cites W4221024206 @default.
• W4310563722 cites W4225011966 @default.
• W4310563722 cites W4280595496 @default.
• W4310563722 doi "https://doi.org/10.1021/acsami.2c18473" @default.
• W4310563722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36459081" @default.
• W4310563722 hasPublicationYear "2022" @default.
• W4310563722 type Work @default.
• W4310563722 citedByCount "4" @default.
• W4310563722 countsByYear W43105637222023 @default.
• W4310563722 crossrefType "journal-article" @default.
• W4310563722 hasAuthorship W4310563722A5000221751 @default.
• W4310563722 hasAuthorship W4310563722A5002809217 @default.
• W4310563722 hasAuthorship W4310563722A5009102045 @default.
• W4310563722 hasAuthorship W4310563722A5017375525 @default.
• W4310563722 hasAuthorship W4310563722A5020321309 @default.
• W4310563722 hasAuthorship W4310563722A5022523046 @default.
• W4310563722 hasAuthorship W4310563722A5091118881 @default.
• W4310563722 hasAuthorship W4310563722A5091388649 @default.
• W4310563722 hasConcept C150394285 @default.
• W4310563722 hasConcept C154881586 @default.
• W4310563722 hasConcept C160756335 @default.
• W4310563722 hasConcept C161790260 @default.
• W4310563722 hasConcept C171250308 @default.
• W4310563722 hasConcept C178790620 @default.
• W4310563722 hasConcept C179366358 @default.
• W4310563722 hasConcept C181199279 @default.
• W4310563722 hasConcept C185592680 @default.
• W4310563722 hasConcept C191503008 @default.
• W4310563722 hasConcept C192562407 @default.
• W4310563722 hasConcept C21951064 @default.
• W4310563722 hasConcept C2776217839 @default.
• W4310563722 hasConcept C2777197210 @default.
• W4310563722 hasConcept C2777723881 @default.
• W4310563722 hasConcept C2779379725 @default.
• W4310563722 hasConcept C552990157 @default.
• W4310563722 hasConcept C55493867 @default.
• W4310563722 hasConcept C58548122 @default.
• W4310563722 hasConcept C84211826 @default.

• next