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- W4310565750 endingPage "114" @default.
- W4310565750 startingPage "103" @default.
- W4310565750 abstract "Abstract HLA class I proteins, a critical component in adaptive immunity, bind and present intracellular Ags to CD8+ T cells. The extreme polymorphism of HLA genes and associated peptide binding specificities leads to challenges in various endeavors, including neoantigen vaccine development, disease association studies, and HLA typing. Supertype classification, defined by clustering functionally similar HLA alleles, has proven helpful in reducing the complexity of distinguishing alleles. However, determining supertypes via experiments is impractical, and current in silico classification methods exhibit limitations in stability and functional relevance. In this study, by incorporating three-dimensional structures we present a method for classifying HLA class I molecules with improved breadth, accuracy, stability, and flexibility. Critical for these advances is our finding that structural similarity highly correlates with peptide binding specificity. The new classification should be broadly useful in peptide-based vaccine development and HLA–disease association studies." @default.
- W4310565750 created "2022-12-12" @default.
- W4310565750 creator A5023716632 @default.
- W4310565750 creator A5037417242 @default.
- W4310565750 creator A5064300096 @default.
- W4310565750 date "2023-01-01" @default.
- W4310565750 modified "2023-09-23" @default.
- W4310565750 title "HLA Class I Supertype Classification Based on Structural Similarity" @default.
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