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- W4310566215 abstract "Undescended testis (UDT) affects 6% of male births. Despite surgical correction, some men with unilateral UDT may experience infertility with the contralateral descended testis (CDT) showing no A-dark spermatogonia. To improve our understanding of the etiology of infertility in UDT, we generated a novel murine model of left unilateral UDT. Gubernaculum-specific Wnt4 knockout (KO) mice (Wnt4-cKO) were generated using retinoic acid receptor β2-cre mice and were found to have a smaller left-unilateral UDT. Wnt4-cKO mice with abdominal UDT had an increase in serum follicle-stimulating hormone and luteinizing hormone and an absence of germ cells in the undescended testicle. Wnt4-cKO mice with inguinal UDT had normal hormonal profiles, and 50% of these mice had no sperm in the left epididymis. Wnt4-cKO mice had fertility defects and produced 52% fewer litters and 78% fewer pups than control mice. Wnt4-cKO testes demonstrated increased expression of estrogen receptor α and SOX9, upregulation of female gonadal genes, and a decrease in male gonadal genes in both CDT and UDT. Several WNT4 variants were identified in boys with UDT. The presence of UDT and fertility defects in Wnt4-cKO mice highlights the crucial role of WNT4 in testicular development." @default.
- W4310566215 created "2022-12-12" @default.
- W4310566215 creator A5003834733 @default.
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- W4310566215 creator A5091702321 @default.
- W4310566215 date "2022-11-30" @default.
- W4310566215 modified "2023-10-06" @default.
- W4310566215 title "Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects" @default.
- W4310566215 cites W1498970130 @default.
- W4310566215 cites W1561174763 @default.
- W4310566215 cites W1563702096 @default.
- W4310566215 cites W1564546210 @default.
- W4310566215 cites W1795583988 @default.
- W4310566215 cites W1882852713 @default.
- W4310566215 cites W1971546287 @default.
- W4310566215 cites W1971689970 @default.
- W4310566215 cites W1973318991 @default.
- W4310566215 cites W1975123653 @default.
- W4310566215 cites W1976751554 @default.
- W4310566215 cites W1978016303 @default.
- W4310566215 cites W1983123884 @default.
- W4310566215 cites W1987740214 @default.
- W4310566215 cites W1993318803 @default.
- W4310566215 cites W1993346200 @default.
- W4310566215 cites W2006594902 @default.
- W4310566215 cites W2010894991 @default.
- W4310566215 cites W2013554143 @default.
- W4310566215 cites W2016548951 @default.
- W4310566215 cites W2021163527 @default.
- W4310566215 cites W2024405748 @default.
- W4310566215 cites W2026668247 @default.
- W4310566215 cites W2035711037 @default.
- W4310566215 cites W2035740049 @default.
- W4310566215 cites W2041369790 @default.
- W4310566215 cites W2041395992 @default.
- W4310566215 cites W2041599430 @default.
- W4310566215 cites W2050128984 @default.
- W4310566215 cites W2050440230 @default.
- W4310566215 cites W2053165529 @default.
- W4310566215 cites W2059145105 @default.
- W4310566215 cites W2062342964 @default.
- W4310566215 cites W2063510509 @default.
- W4310566215 cites W2064050001 @default.
- W4310566215 cites W2065054448 @default.
- W4310566215 cites W2066569158 @default.
- W4310566215 cites W2068099072 @default.
- W4310566215 cites W2076357933 @default.
- W4310566215 cites W2076962720 @default.
- W4310566215 cites W2082781405 @default.
- W4310566215 cites W2083356835 @default.
- W4310566215 cites W2084294589 @default.
- W4310566215 cites W2091675632 @default.
- W4310566215 cites W2095268881 @default.
- W4310566215 cites W2098412813 @default.
- W4310566215 cites W2101585008 @default.
- W4310566215 cites W2104135721 @default.
- W4310566215 cites W2105332162 @default.
- W4310566215 cites W2105695731 @default.
- W4310566215 cites W2116186946 @default.
- W4310566215 cites W2117925584 @default.
- W4310566215 cites W2120258670 @default.
- W4310566215 cites W2120772351 @default.
- W4310566215 cites W2122038030 @default.
- W4310566215 cites W2124026197 @default.
- W4310566215 cites W2124943870 @default.
- W4310566215 cites W2126075084 @default.
- W4310566215 cites W2126521585 @default.
- W4310566215 cites W2127626509 @default.
- W4310566215 cites W2131418870 @default.
- W4310566215 cites W2132629607 @default.
- W4310566215 cites W2134638008 @default.
- W4310566215 cites W2138956466 @default.
- W4310566215 cites W2140861044 @default.
- W4310566215 cites W2140897200 @default.
- W4310566215 cites W2142666322 @default.
- W4310566215 cites W2143424517 @default.
- W4310566215 cites W2151331867 @default.
- W4310566215 cites W2153185762 @default.
- W4310566215 cites W2158120612 @default.
- W4310566215 cites W2158701974 @default.
- W4310566215 cites W2160276016 @default.
- W4310566215 cites W2160881289 @default.
- W4310566215 cites W2164089374 @default.
- W4310566215 cites W2169503556 @default.
- W4310566215 cites W2170573225 @default.
- W4310566215 cites W2192853098 @default.
- W4310566215 cites W2336311267 @default.
- W4310566215 cites W2376073088 @default.
- W4310566215 cites W2440773649 @default.
- W4310566215 cites W2522574654 @default.
- W4310566215 cites W2595105860 @default.
- W4310566215 cites W2790488381 @default.
- W4310566215 cites W2791872035 @default.
- W4310566215 cites W2800056055 @default.