Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310567109> ?p ?o ?g. }
- W4310567109 endingPage "1582" @default.
- W4310567109 startingPage "1569" @default.
- W4310567109 abstract "Oxylipins are enzymatic and non-enzymatic metabolites of mono- or polyunsaturated fatty acids that encompass potent lipid mediators including the eicosanoids and docosanoids. Previously considered of low interest and often dismissed as ‘just fat', octadecanoid oxylipins have only recently begun to be recognized as lipid mediators in humans. In the last few years, these compounds have been found to be involved in the mediation of multiple biological processes related to nociception, tissue modulation, cell proliferation, metabolic regulation, inflammation, and immune regulation. At the same time, the study of octadecanoids is hampered by a lack of standardization in the field, a paucity of analytical standards, and a lack of domain expertise. These issues have collectively limited the investigation of the biosynthesis and bioactivity of octadecanoids. Here, we present an overview of the primary enzymatic pathways for the oxidative metabolism of 18-carbon fatty acids in humans and of the current knowledge of the major biological activity of the resulting octadecanoids. We also propose a systematic nomenclature system based upon that used for the eicosanoids in order to avoid ambiguities and resolve multiple designations for the same octadecanoid. The aim of this review is to provide an initial framework for the field and to assist in its standardization as well as to increase awareness of this class of compounds in order to stimulate research into this interesting group of lipid mediators." @default.
- W4310567109 created "2022-12-12" @default.
- W4310567109 creator A5053908111 @default.
- W4310567109 creator A5057500645 @default.
- W4310567109 creator A5083447947 @default.
- W4310567109 date "2022-12-01" @default.
- W4310567109 modified "2023-09-30" @default.
- W4310567109 title "The octadecanoids: an emerging class of lipid mediators" @default.
- W4310567109 cites W1520750411 @default.
- W4310567109 cites W1628945555 @default.
- W4310567109 cites W1639439950 @default.
- W4310567109 cites W1766122222 @default.
- W4310567109 cites W1947800358 @default.
- W4310567109 cites W1965062785 @default.
- W4310567109 cites W1967818422 @default.
- W4310567109 cites W1970763764 @default.
- W4310567109 cites W1972101838 @default.
- W4310567109 cites W1977087029 @default.
- W4310567109 cites W1977122892 @default.
- W4310567109 cites W1984238073 @default.
- W4310567109 cites W1984757473 @default.
- W4310567109 cites W1986432287 @default.
- W4310567109 cites W1986852234 @default.
- W4310567109 cites W1987124995 @default.
- W4310567109 cites W1991656166 @default.
- W4310567109 cites W1991844540 @default.
- W4310567109 cites W1993375748 @default.
- W4310567109 cites W2003719859 @default.
- W4310567109 cites W2004213334 @default.
- W4310567109 cites W2008649669 @default.
- W4310567109 cites W2013308216 @default.
- W4310567109 cites W2015519617 @default.
- W4310567109 cites W2020874061 @default.
- W4310567109 cites W2023362496 @default.
- W4310567109 cites W2024176341 @default.
- W4310567109 cites W2027037066 @default.
- W4310567109 cites W2028143378 @default.
- W4310567109 cites W2028705982 @default.
- W4310567109 cites W2029387641 @default.
- W4310567109 cites W2030297321 @default.
- W4310567109 cites W2036493346 @default.
- W4310567109 cites W2047223968 @default.
- W4310567109 cites W2051736472 @default.
- W4310567109 cites W2052624151 @default.
- W4310567109 cites W2054587562 @default.
- W4310567109 cites W2055291719 @default.
- W4310567109 cites W2060035882 @default.
- W4310567109 cites W2061837477 @default.
- W4310567109 cites W2062159267 @default.
- W4310567109 cites W2064563274 @default.
- W4310567109 cites W2065377708 @default.
- W4310567109 cites W2065806578 @default.
- W4310567109 cites W2071534982 @default.
- W4310567109 cites W2074356915 @default.
- W4310567109 cites W2076653387 @default.
- W4310567109 cites W2078885177 @default.
- W4310567109 cites W2081303579 @default.
- W4310567109 cites W2082320092 @default.
- W4310567109 cites W2084081792 @default.
- W4310567109 cites W2087647782 @default.
- W4310567109 cites W2089923844 @default.
- W4310567109 cites W2090609282 @default.
- W4310567109 cites W2091815889 @default.
- W4310567109 cites W2096719701 @default.
- W4310567109 cites W2101841000 @default.
- W4310567109 cites W2114381382 @default.
- W4310567109 cites W2117234604 @default.
- W4310567109 cites W2117994717 @default.
- W4310567109 cites W212643890 @default.
- W4310567109 cites W2140950206 @default.
- W4310567109 cites W2146125855 @default.
- W4310567109 cites W2147271582 @default.
- W4310567109 cites W2147971048 @default.
- W4310567109 cites W2150741190 @default.
- W4310567109 cites W2158179602 @default.
- W4310567109 cites W2285241395 @default.
- W4310567109 cites W2312815678 @default.
- W4310567109 cites W2334483311 @default.
- W4310567109 cites W2338418581 @default.
- W4310567109 cites W2344485917 @default.
- W4310567109 cites W2346239303 @default.
- W4310567109 cites W2396452750 @default.
- W4310567109 cites W2509635278 @default.
- W4310567109 cites W2521042841 @default.
- W4310567109 cites W2598224504 @default.
- W4310567109 cites W2605253263 @default.
- W4310567109 cites W2741910696 @default.
- W4310567109 cites W2745426617 @default.
- W4310567109 cites W2753988219 @default.
- W4310567109 cites W2788737826 @default.
- W4310567109 cites W2795441976 @default.
- W4310567109 cites W2800024870 @default.
- W4310567109 cites W2809724179 @default.
- W4310567109 cites W2884190792 @default.
- W4310567109 cites W2901710743 @default.
- W4310567109 cites W2946024917 @default.
- W4310567109 cites W2963614304 @default.
- W4310567109 cites W2971602650 @default.