Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310571093> ?p ?o ?g. }
- W4310571093 abstract "There is an ongoing debate about the value of animal research in psychiatry with valid lines of reasoning stating the limits of individual animal models compared to human psychiatric illnesses. Human depression is not a homogenous disorder; therefore, one cannot expect a single animal model to reflect depression heterogeneity. This limited review presents arguments that the Wistar Kyoto (WKY) rats show intrinsic depression traits. The phenotypes of WKY do not completely mirror those of human depression but clearly indicate characteristics that are common with it. WKYs present despair- like behavior, passive coping with stress, comorbid anxiety, and enhanced drug use compared to other routinely used inbred or outbred strains of rats. The commonly used tests identifying these phenotypes reflect exploratory, escape-oriented, and withdrawal-like behaviors. The WKYs consistently choose withdrawal or avoidance in novel environments and freezing behaviors in response to a challenge in these tests. The physiological response to a stressful environment is exaggerated in WKYs. Selective breeding generated two WKY substrains that are nearly isogenic but show clear behavioral differences, including that of depression-like behavior. WKY and its substrains may share characteristics of subgroups of depressed individuals with social withdrawal, low energy, weight loss, sleep disturbances, and specific cognitive dysfunction. The genomes of the WKY and WKY substrains contain variations that impact the function of many genes identified in recent human genetic studies of depression. Thus, these strains of rats share characteristics of human depression at both phenotypic and genetic levels, making them a model of depression traits." @default.
- W4310571093 created "2022-12-12" @default.
- W4310571093 creator A5006618040 @default.
- W4310571093 creator A5020700114 @default.
- W4310571093 creator A5022499603 @default.
- W4310571093 creator A5085430517 @default.
- W4310571093 date "2022-11-29" @default.
- W4310571093 modified "2023-10-12" @default.
- W4310571093 title "The Wistar Kyoto rat: a model of depression traits" @default.
- W4310571093 cites W1688029329 @default.
- W4310571093 cites W1830412493 @default.
- W4310571093 cites W1875915725 @default.
- W4310571093 cites W1906511644 @default.
- W4310571093 cites W1936885761 @default.
- W4310571093 cites W1941293036 @default.
- W4310571093 cites W1964261039 @default.
- W4310571093 cites W1964289699 @default.
- W4310571093 cites W1967514749 @default.
- W4310571093 cites W1967859998 @default.
- W4310571093 cites W1971639265 @default.
- W4310571093 cites W1972220682 @default.
- W4310571093 cites W1972246855 @default.
- W4310571093 cites W1972499031 @default.
- W4310571093 cites W1973055270 @default.
- W4310571093 cites W1973530447 @default.
- W4310571093 cites W1975187292 @default.
- W4310571093 cites W1975969692 @default.
- W4310571093 cites W1977886842 @default.
- W4310571093 cites W1980374662 @default.
- W4310571093 cites W1981094037 @default.
- W4310571093 cites W1981748148 @default.
- W4310571093 cites W1982937128 @default.
- W4310571093 cites W1984078964 @default.
- W4310571093 cites W1986202839 @default.
- W4310571093 cites W1986622093 @default.
- W4310571093 cites W1986753057 @default.
- W4310571093 cites W1986901635 @default.
- W4310571093 cites W1987450364 @default.
- W4310571093 cites W1988798827 @default.
- W4310571093 cites W1989052921 @default.
- W4310571093 cites W1989119049 @default.
- W4310571093 cites W1989348564 @default.
- W4310571093 cites W1991527095 @default.
- W4310571093 cites W1991766265 @default.
- W4310571093 cites W1993263854 @default.
- W4310571093 cites W1993364340 @default.
- W4310571093 cites W1994124031 @default.
- W4310571093 cites W1996465490 @default.
- W4310571093 cites W1999582393 @default.
- W4310571093 cites W1999936492 @default.
- W4310571093 cites W2001475683 @default.
- W4310571093 cites W2004347423 @default.
- W4310571093 cites W2004601441 @default.
- W4310571093 cites W2005817345 @default.
- W4310571093 cites W2006000660 @default.
- W4310571093 cites W2007725381 @default.
- W4310571093 cites W2008635205 @default.
- W4310571093 cites W2009119606 @default.
- W4310571093 cites W2010167850 @default.
- W4310571093 cites W2010863510 @default.
- W4310571093 cites W2011816953 @default.
- W4310571093 cites W2012109041 @default.
- W4310571093 cites W2017006044 @default.
- W4310571093 cites W2017836063 @default.
- W4310571093 cites W2017868252 @default.
- W4310571093 cites W2018342377 @default.
- W4310571093 cites W2019065360 @default.
- W4310571093 cites W2020858381 @default.
- W4310571093 cites W2022356586 @default.
- W4310571093 cites W2023414423 @default.
- W4310571093 cites W2026677009 @default.
- W4310571093 cites W2028086494 @default.
- W4310571093 cites W2028808028 @default.
- W4310571093 cites W2028904621 @default.
- W4310571093 cites W2029319050 @default.
- W4310571093 cites W2034119281 @default.
- W4310571093 cites W2034189826 @default.
- W4310571093 cites W2036188372 @default.
- W4310571093 cites W2039070256 @default.
- W4310571093 cites W2040697895 @default.
- W4310571093 cites W2042924921 @default.
- W4310571093 cites W2043480169 @default.
- W4310571093 cites W2043836823 @default.
- W4310571093 cites W2044362258 @default.
- W4310571093 cites W2045217164 @default.
- W4310571093 cites W2046216444 @default.
- W4310571093 cites W2046324252 @default.
- W4310571093 cites W2049701258 @default.
- W4310571093 cites W2049895955 @default.
- W4310571093 cites W2050021971 @default.
- W4310571093 cites W2050836998 @default.
- W4310571093 cites W2052312283 @default.
- W4310571093 cites W2054847765 @default.
- W4310571093 cites W2057600258 @default.
- W4310571093 cites W2058312442 @default.
- W4310571093 cites W2058717577 @default.
- W4310571093 cites W2058878434 @default.
- W4310571093 cites W2059565695 @default.
- W4310571093 cites W2060191609 @default.
- W4310571093 cites W2062656924 @default.